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TMED9-SEC12, an important 'contact' for autophagy
- Source :
- Cell research. 32(2)
- Publication Year :
- 2023
-
Abstract
- Autophagosome biogenesis occurs via a complex mechanism that involves membranes from different subcellular compartments. Here, we review an elegant study from Li et al. describing a new type of ERGIC-ERES membrane contact mediated by TMED9 and SEC12 that leads to the formation of COPII-coated vesicles essential for the formation of the autophagosome, and attempt to reconcile their findings with our studies proposing that the recycling endosome is a core platform for autophagosome biogenesis.
Details
- ISSN :
- 17487838
- Volume :
- 32
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Cell research
- Accession number :
- edsair.doi.dedup.....19f2ce2444bce66fea81d5e60bead02f