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Cone damage in patients receiving high-dose irofulven treatment
- Source :
- Archives of ophthalmology (Chicago, Ill. : 1960). 123(1)
- Publication Year :
- 2005
-
Abstract
- Objectives: To describe the clinical, perimetric, and electroretinographic (ERG) results of 4 patients with cone dysfunction following irofulven treatment including the histopathologic and immunocytochemical features of one patient’s retinas. Design: Observational case series. Methods: The patients were examined clinically, including perimetric and ERG evaluations. Eyes from patient 1 and healthy postmortem eyes were processed for histopathologic and immunocytochemistry studies with antibodies specific for cones, rods, and reactive Muller cells. Main Outcome Measures: Clinical signs and symptoms, perimetry, ERG, retinal histopathologic and immunocytochemistry study results. Results: All 4 patients had ERG changes consistent with abnormal cone responses and relatively normal rod responses. Compared with control eyes, the retina of patient 1 had approximately half the normal numbers of macular cones and fewer peripheral cones. The number of rods were normal but all rod and cone outer segments were shortened. Conclusion: High-dose irofulven treatment causes conespecific damage with relative sparing of rods. Arch Ophthalmol. 2005;123:29-34
- Subjects :
- Adult
Pathology
medicine.medical_specialty
Rhodopsin
genetic structures
Eye disease
Immunocytochemistry
Lesion
chemistry.chemical_compound
Retinal Diseases
Neoplasms
Glial Fibrillary Acidic Protein
medicine
Electroretinography
Irofulven
Humans
Fluorescent Antibody Technique, Indirect
Antineoplastic Agents, Alkylating
Aged
Retina
business.industry
Retinal
Middle Aged
medicine.disease
eye diseases
Peripheral
Ophthalmology
medicine.anatomical_structure
chemistry
Retinal Cone Photoreceptor Cells
Visual Field Tests
Female
sense organs
medicine.symptom
Visual Fields
business
Erg
Sesquiterpenes
Subjects
Details
- ISSN :
- 00039950
- Volume :
- 123
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Archives of ophthalmology (Chicago, Ill. : 1960)
- Accession number :
- edsair.doi.dedup.....19ec26e4f1e5e8121af3dac9a28d0712