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Severe mortality impact of the 1957 influenza pandemic in Chile
- Source :
- Influenza and Other Respiratory Viruses
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- Introduction Epidemiological studies of the 1957 influenza pandemic are scarce, particularly from lower-income settings. Methods We analyzed the spatial-temporal mortality patterns of the 1957 influenza pandemic in Chile, including detailed age-specific mortality data from a large city, and investigated risk factors for severe mortality impact across regions. Results Chile exhibited two waves of excess mortality in winter 1957 and 1959 with a cumulative excess mortality rate of 12 per 10 000, and a ~10-fold mortality difference across provinces. High excess mortality rates were associated with high baseline mortality (R2 =41.8%; P=.02), but not with latitude (P>.7). Excess mortality rates increased sharply with age. Transmissibility declined from R=1.4-2.1 to R=1.2-1.4 between the two pandemic waves. Conclusions The estimated A/H2N2 mortality burden in Chile is the highest on record for this pandemic-about three to five times as severe as that experienced in wealthier nations. The global impact of this pandemic may be substantially underestimated from previous studies based on high-income countries.
- Subjects :
- Adult
0301 basic medicine
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Adolescent
Epidemiology
Young Adult
03 medical and health sciences
Age Distribution
0302 clinical medicine
Influenza, Human
Pandemic
medicine
Humans
baseline mortality rates
transmissibility
030212 general & internal medicine
Chile
Child
Large city
Pandemics
Aged
Excess mortality
business.industry
Public Health, Environmental and Occupational Health
reproduction number
latitude
Original Articles
excess mortality rates
Middle Aged
Influenza pandemic
1957 influenza pandemic
Virology
030104 developmental biology
Infectious Diseases
Influenza A virus
Mortality data
Child, Preschool
Human mortality from H5N1
Female
Original Article
Seasons
business
Demography
Subjects
Details
- ISSN :
- 17502640
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Influenza and Other Respiratory Viruses
- Accession number :
- edsair.doi.dedup.....19e1fd3c78c29f7f0148699dbcff36f4