Bioavailability and Safety of Dihydroquercetin (Review)

Authors :: S V, Orlova
V V, Tatarinov
E A, Nikitina
A V, Sheremeta
V A, Ivlev
V G, Vasil'ev
K V, Paliy
S V, Goryainov
Source :: Pharmaceutical Chemistry Journal. 55:1133-1137
Publication Year :: 2022
Publisher :: Springer Science and Business Media LLC, 2022.
Abstract: Dihydroquercetin (DHQ) is a bioflavonoid with high antioxidant, capillary-protective, and anti-inflammatory activity. DHQ has previously been used for treating Middle East respiratory syndrome coronavirus (MERS-CoV) infection and is currently considered a potential regulator of oxidative stress as part of COVID-19 multipurpose therapy. DHQ has a high safety profile but low bioavailability that limits its use. Innovative techniques (liposomization, crystal engineering, etc.) can be used to increase its bioavailability.