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Acute inhibition of kappa opioid receptors before stress blocks depression-like behaviors in California mice
- Source :
- Progress in Neuro-Psychopharmacology and Biological Psychiatry. 86:166-174
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Kappa opioid receptors (KOR) are considered to be a promising therapeutic target for stress-induced psychiatric disorders such as anxiety and depression. Preclinical data show that KOR antagonists have greater efficacy if administered before stressful experiences as opposed to afterwards. However, almost all of these studies use long-acting antagonists, leaving it unclear whether inhibition of KOR after stress is required for efficacy. Here we show that administration of the short-acting KOR antagonist AZ-MTAB before episodes of social defeat stress block the induction of anhedonia (both males and females) and social avoidance responses (females) that persist two weeks after stress. In both males and females pre-stress AZ-MTAB treatment also blunted anticipatory autogrooming behavior immediately prior to the third episode of defeat. In contrast when AZ-MTAB was administered two weeks after defeat (immediately before behavior testing) in female California mice, it was ineffective at reversing anhedonia and social avoidance. These results suggest that short-acting KOR antagonists may have greater therapeutic potential if administered before exposure to psychosocial stressors.
- Subjects :
- Male
0301 basic medicine
Anhedonia
Social interaction
Medical and Health Sciences
Social defeat
Random Allocation
0302 clinical medicine
Receptors
Depression (differential diagnoses)
Psychiatry
Behavior, Animal
Arvicolinae
Depression
Mental Health
Anxiety
Female
medicine.symptom
Social defeat stress
Psychosocial
medicine.medical_specialty
Clinical Sciences
Opioid
Stress
Basic Behavioral and Social Science
κ-opioid receptor
Article
03 medical and health sciences
Kappa opioid receptor
Internal medicine
Behavioral and Social Science
medicine
Animals
kappa
Biological Psychiatry
Pharmacology
Psychotropic Drugs
Behavior
Depressive Disorder
Animal
business.industry
Receptors, Opioid, kappa
Psychology and Cognitive Sciences
Neurosciences
Antagonist
Social relation
Brain Disorders
030104 developmental biology
Endocrinology
Psychological
business
Stress, Psychological
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 02785846
- Volume :
- 86
- Database :
- OpenAIRE
- Journal :
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Accession number :
- edsair.doi.dedup.....19d56b6def4c8a5c39ccfc9bc138ef8d