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Attitudes toward the right to autonomous decision‐making in psychiatric genetic testing: Controversial and context‐dependent
- Source :
- American Journal of Medical Genetics
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- Recent breakthroughs in psychiatric genetics have identified genetic risk factors of yet unknown clinical value. A main ethical principal in the context of psychiatric research as well as future clinical genetic testing is the respect for a person's autonomy to decide whether to undergo genetic testing, and whom to grant access to genetic data. However, experience within the psychiatric genetic research setting has indicated controversies surrounding attitudes toward this ethical principal. This study aimed to explore attitudes concerning the right of individuals to self-determine testing and disclosure of results, and to determine whether these attitudes are context-dependent, that is, not directly related to the test result but rather to specific circumstances. N = 160 individuals with major depression or bipolar disorder and n = 29 relatives of individuals with either illness completed an online-questionnaire assessing attitudes toward genetic testing, genetic research, disclosure of results, incidental findings, and access to psychiatric genetic test results. Generally, the right of the person's autonomy was considered very important, but attitudes varied. For example, half of those who considered that children should have the right to refuse psychiatric genetic testing even against their parents' will, also state that they should be tested upon their parents' wishes. Also, the majority of respondents considered the physician entitled to disregard their stated wishes concerning the disclosure of incidental findings in case of good treatment options. Thus, researchers and clinicians must be aware that attitudes toward psychiatric genetic testing are often mutable and should discuss these prior to testing. peerReviewed
- Subjects :
- Adult
Male
0301 basic medicine
Genetic Research
medicine.medical_specialty
Bipolar Disorder
media_common.quotation_subject
Decision Making
ambivalence
Genetic Counseling
Context (language use)
Disclosure
030105 genetics & heredity
privacy
Ambivalence
03 medical and health sciences
Cellular and Molecular Neuroscience
Risk Factors
right to self‐determination
Surveys and Questionnaires
medicine
Humans
Genetic Testing
Bipolar disorder
Psychiatry
Research Articles
Genetics (clinical)
Depression (differential diagnoses)
Psychiatric genetics
media_common
Genetic testing
Depressive Disorder, Major
medicine.diagnostic_test
Mental Disorders
Genomics
16. Peace & justice
medicine.disease
Test (assessment)
Psychiatry and Mental health
030104 developmental biology
Attitude
psychiatric genetic testing
right to self-determination
Female
Psychology
Attitude to Health
Autonomy
Research Article
Subjects
Details
- ISSN :
- 1552485X and 15524841
- Volume :
- 180
- Database :
- OpenAIRE
- Journal :
- American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
- Accession number :
- edsair.doi.dedup.....19d3f5e12ecbabce198d169f25a308b2