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The clinical significance of tumor-infiltrating neutrophils and neutrophil-to-CD8+ lymphocyte ratio in patients with resectable esophageal squamous cell carcinoma
- Source :
- Journal of Translational Medicine
- Publisher :
- Springer Nature
-
Abstract
- Background The interaction between tumor cells and inflammatory cells has not been systematically investigated in esophageal squamous cell carcinoma (ESCC). The main aims of the study were to investigate the clinical significance of tumor-infiltrating neutrophils and neturophil-to-CD8+ lymphocyte ratio (NLR), and to analyze the distribution of tumor-infiltrating neutrophils and CD8+ lymphocytes in ESCC treated by curative resection. Methods The expressions of CD66b and CD8 were assessed with double staining immunohistochemistry in the surgical specimens from 90 patients with ESCC treated by curative surgery. Results We showed that increased intratumoral neutrophils were significantly associated with lymph node metastasis (P = 0.016), and advanced pathological stages (P = 0.013). Decreased peritumoral CD8+ lymphocyte density was more frequently observed in patients with single positive lymph node (p = 0.045). Peritumoral NLR was significantly associated with advanced T stages (p Conclusions Increased intratumoral neutrophils were an independent poor prognostic factor and peritumoral NLR was significantly associated with disease progression in ESCC treated by curative surgery, suggesting the possible effect of immune misbalance of tumor microenvironment in facilitating ESCC progression. Immunotherapy targeted to the above predictors should be considered in the future.
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Microenvironment
Esophageal Neoplasms
medicine.medical_treatment
Lymphocyte
Kaplan-Meier Estimate
CD8-Positive T-Lymphocytes
Biology
General Biochemistry, Genetics and Molecular Biology
Lymphocytes, Tumor-Infiltrating
Immune system
Esophageal squamous cell carcinoma
Antigens, CD
medicine
Humans
Clinical significance
Intratumoral neutrophils
Aged
Medicine(all)
Tumor microenvironment
Univariate analysis
Biochemistry, Genetics and Molecular Biology(all)
Research
General Medicine
Immunotherapy
Middle Aged
Immunohistochemistry
medicine.anatomical_structure
Neutrophil Infiltration
Multivariate Analysis
Carcinoma, Squamous Cell
Female
Neturophil-to-CD8+ lymphocyte ratio
Cell Adhesion Molecules
CD8
Subjects
Details
- Language :
- English
- ISSN :
- 14795876
- Volume :
- 12
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of Translational Medicine
- Accession number :
- edsair.doi.dedup.....19c492c6ce4b77b9d4b279d239f3af96
- Full Text :
- https://doi.org/10.1186/1479-5876-12-7