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How do surface properties of nanoparticles influence their diffusion in the extracellular matrix? A model study in Matrigel using polymer-grafted nanoparticles
- Source :
- Langmuir, Langmuir, American Chemical Society, In press, 36, pp.10460-10470. ⟨10.1021/acs.langmuir.0c01624⟩, Langmuir, 2020, 36, pp.10460-10470. ⟨10.1021/acs.langmuir.0c01624⟩
- Publication Year :
- 2020
- Publisher :
- HAL CCSD, 2020.
-
Abstract
- Diffusion of nanomedicines inside the extracellular matrix (ECM) has been identified as a key factor to achieve homogeneous distribution and therefore therapeutic efficacy. Here, we sought to determine the impact of nanoparticles' (NPs) surface properties on their ability to diffuse in the ECM. As model nano-objects, we used a library of gold nanoparticles grafted with a versatile polymethacrylate corona, which enabled the surface properties to be modified. To accurately recreate the features of the native ECM, diffusion studies were carried out in a tumor-derived gel (Matrigel). We developed two methods to evaluate the diffusion ability of NPs inside this model gel: an easy-to-implement one based on optical monitoring and another one using small-angle X-ray scattering (SAXS) measurements. Both enabled the determination of the diffusion coefficients of NPs and comparison of the influence of their various surface properties, while the SAXS technique also allowed to monitor the NPs' structure as they diffused inside the gel. Positive charges and hydrophobicity were found to particularly hinder diffusion, and the different results suggested on the whole the presence of NPs-matrix interactions, therefore underlying the importance of the ECM model. The accuracy of the tumor-derived gels used in this study was evidenced by in vivo experiments involving intratumoral injections of NPs on mice, which showed that diffusion patterns in the peripheral tumor tissues were quite similar to the ones obtained within the chosen ECM model.
- Subjects :
- Materials science
Polymers
Surface Properties
Diffusion
Metal Nanoparticles
Nanoparticle
02 engineering and technology
010402 general chemistry
01 natural sciences
Homogeneous distribution
Extracellular matrix
Mice
X-Ray Diffraction
Scattering, Small Angle
Electrochemistry
Animals
General Materials Science
Spectroscopy
chemistry.chemical_classification
Matrigel
Small-angle X-ray scattering
Surfaces and Interfaces
Polymer
[CHIM.MATE]Chemical Sciences/Material chemistry
021001 nanoscience & nanotechnology
Condensed Matter Physics
Extracellular Matrix
0104 chemical sciences
Drug Combinations
chemistry
Colloidal gold
Biophysics
Nanoparticles
Proteoglycans
Collagen
Gold
Laminin
0210 nano-technology
Subjects
Details
- Language :
- English
- ISSN :
- 07437463 and 15205827
- Database :
- OpenAIRE
- Journal :
- Langmuir, Langmuir, American Chemical Society, In press, 36, pp.10460-10470. ⟨10.1021/acs.langmuir.0c01624⟩, Langmuir, 2020, 36, pp.10460-10470. ⟨10.1021/acs.langmuir.0c01624⟩
- Accession number :
- edsair.doi.dedup.....19be3f3262dd07744bfbc5d3c46f0a72