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Pharmacological strategies against cold ischemia reperfusion injury
- Source :
- Digital.CSIC. Repositorio Institucional del CSIC, instname
- Publication Year :
- 2010
-
Abstract
- Importance of the field: Good organ preservation is a determinant of graft outcome after revascularization. The necessity of increasing the quality of organ preservation, as well as of extending cold storage time, has made it necessary to consider the use of pharmacological additives. Areas covered in this review: The complex physiopathology of cold-ischemia-reperfusion (I/R) injury - and in particular cell death, mitochondrial injury and endoplasmic reticulum stress - are reviewed. Basic principles of the formulation of the different preservation solutions are discussed. What the reader will gain: Current strategies and new trends in static organ preservation using additives such as trimetazidine, polyethylene glycols, melatonin, trophic factors and endothelin antagonists in solution are presented and discussed. The benefits and mechanisms responsible for enhancing organ protection against I/R injury are also discussed. Graft preservation was substantially improved when additives were added to the preservation solutions. Take home message: Enrichment of preservation solutions by additives is clinically useful only for short periods. For longer periods of cold ischemia, the use of such additives becomes insufficient because graft function deteriorates as a result of ischemia. In such conditions, the preservation strategy should be changed by the use of machine perfusion in normothermic conditions. © 2010 Informa UK Ltd.<br />This study was supported by the Ministerio de Sanidad y Consumo (PI081988), CIBER-ehd, Instituto Carlos III, Madrid and Ministerio de Asuntos Exteriores y de Cooperacion Internacionales (A/020255/08), (A/029087/09), Madrid. MA Zaouali is a fellow of the Societat Catalana de Trasplantament.
- Subjects :
- medicine.hormone
Endothelin Receptor Antagonists
Tissue and Organ Procurement
medicine.medical_treatment
Organ Preservation Solutions
Trimetazidine
Cold storage
Pharmacology
Revascularization
Polyethylene Glycols
Endothelins
medicine
Preservation solutions
Humans
Pharmacology (medical)
Cold ischemia
Melatonin
business.industry
Cold Ischemia
General Medicine
Organ Preservation
medicine.disease
Cold Temperature
Perfusion
Anesthesia
Reperfusion Injury
Intercellular Signaling Peptides and Proteins
business
Reperfusion injury
medicine.drug
Graft preservation
Subjects
Details
- ISSN :
- 17447666
- Volume :
- 11
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Expert opinion on pharmacotherapy
- Accession number :
- edsair.doi.dedup.....19b70e2bca262909f722780655148e99