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Estimated Glomerular Filtration Rate in Renal Transplantation
- Source :
- Transplantation. 99:2625-2633
- Publication Year :
- 2015
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2015.
-
Abstract
- Background Formulas do not estimate renal function with acceptable precision and accuracy. Methods We compared 51 creatinine-based and/or cystatin c-based formulas with a gold standard (iohexol plasma clearance) in 193 renal transplant recipients using concordance correlation coefficient, total deviation index, coverage probability and the error in chronic kidney disease (CKD) stage classification. Results No formula showed a concordance correlation coefficient greater than 0.90 (average for creatinine-based formulas: ∼0.70 and for cystatin c-based formulas: ∼0.85). A wide total deviation index was observed: approximately 70% (creatinine-based) and approximately 50% (cystatin c-based), indicating that 90% of the estimations showed bounds of error of ±70% or ±50%, respectively, compared with the gold standard. No formula included 90% of the estimations within a coverage probability of ±10%. Half the CKD stages classified by creatinine-based formulas were incorrect, mainly due to overestimation of renal function. One of 3 CKD stages diagnosed by cystatin c-based formulas was incorrect, with both overestimation and underestimation. Overall, the formulas showed very low precision and accuracy and a high degree of error in reflecting real renal function. Conclusions In conclusion, formulas do not properly reflect renal function in kidney transplantation, which makes their use in clinical practice unreliable. Moreover, their use in clinical trials should be avoided.
- Subjects :
- Male
Nephrology
medicine.medical_specialty
Coverage probability
Urology
Renal function
Kidney Function Tests
urologic and male genital diseases
chemistry.chemical_compound
Internal medicine
medicine
Humans
Renal Insufficiency, Chronic
Kidney transplantation
Transplantation
Creatinine
business.industry
Graft Survival
Middle Aged
Prognosis
medicine.disease
Kidney Transplantation
Transplant Recipients
Surgery
Cross-Sectional Studies
Concordance correlation coefficient
chemistry
Female
business
Follow-Up Studies
Glomerular Filtration Rate
Kidney disease
Subjects
Details
- ISSN :
- 00411337
- Volume :
- 99
- Database :
- OpenAIRE
- Journal :
- Transplantation
- Accession number :
- edsair.doi.dedup.....19b5bdaadc9dec7c57ed3a6c4d0d221a