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Effect of preoperative statins in patients without coronary artery disease who undergo cardiac surgery
- Source :
- The Journal of Thoracic and Cardiovascular Surgery. 136:1510-1513
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- Objective 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have been shown to have pleiotropic effects in addition to their lipid-lowering properties. Some studies have shown the beneficial effect of preoperative statins on operative outcomes in coronary artery bypass grafting. However, the effect of preoperative statins in patients without coronary artery disease who undergo cardiac surgery remains poorly defined. Methods We performed a retrospective review of 1389 consecutive patients undergoing cardiac valve surgery between January of 2002 and December of 2005. Patients undergoing concomitant coronary artery bypass surgery and those with a history of myocardial infarction and coronary interventions were excluded. Of this cohort, 363 patients were receiving a statin preoperatively and 1026 patients were not. Propensity scores were constructed with patients' demographics, clinical data, and the year of procedure. Generalized estimating equations, including the propensity score as a covariate, were used to investigate whether preoperative statin use is associated with improved operative outcomes. Results The crude operative mortality rate was 0.8% and 2.3%, the incidence of stroke was 1.7% and 2.9%, and the incidence of perioperative myocardial infarction was 2.2% and 2.4% in the statin and non-statin groups, respectively. Generalized estimating equations showed that preoperative statin use is associated with lower mortality (odds ratio: 0.25, 95% confidential interval: 0.12–0.54). Preoperative statin use was not significantly associated with an incidence of stroke (odds ratio: 0.48, 95% confidential interval: 0.19–1.22) or perioperative myocardial infarction (odds ratio: 0.91, 95% confidential interval: 0.43–1.91) in this cohort. Conclusion Preoperative use of statins may improve operative outcomes in patients without coronary artery disease who undergo cardiac surgery.
- Subjects :
- Adult
Male
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Statin
Heart Diseases
medicine.drug_class
Coronary Artery Disease
Coronary artery disease
Coronary artery bypass surgery
Internal medicine
Preoperative Care
medicine
Humans
cardiovascular diseases
Myocardial infarction
Cardiac Surgical Procedures
Stroke
Aged
Retrospective Studies
business.industry
Odds ratio
Perioperative
Middle Aged
medicine.disease
Cardiac surgery
Surgery
Cardiology
Female
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 00225223
- Volume :
- 136
- Database :
- OpenAIRE
- Journal :
- The Journal of Thoracic and Cardiovascular Surgery
- Accession number :
- edsair.doi.dedup.....19b39ec3f7c369eb7248a31781ca801d