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Speckle contrast diffuse correlation tomography of cerebral blood flow in perinatal disease model of neonatal piglets
- Source :
- J Biophotonics
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- We adapted and tested an innovative noncontact speckle contrast diffuse correlation tomography (scDCT) system for 3D imaging of cerebral blood flow (CBF) variations in perinatal disease models utilizing neonatal piglets, which closely resemble human neonates. CBF variations were concurrently measured by the scDCT and an established diffuse correlation spectroscopy (DCS) during global ischemia, intraventricular hemorrhage, and asphyxia; significant correlations were observed. Moreover, CBF variations associated reasonably with vital pathophysiological changes. In contrast to DCS measurements of mixed signals from local scalp, skull and brain, scDCT generates 3D images of CBF distributions at prescribed depths within the head, thus enabling specific determination of regional cerebral ischemia. With further optimization and validation in animals and human neonates, scDCT has the potential to be a noninvasive imaging tool for both basic neuroscience research in laboratories and clinical applications in neonatal intensive care units.
- Subjects :
- medicine.medical_specialty
Swine
media_common.quotation_subject
Ischemia
General Physics and Astronomy
01 natural sciences
Article
General Biochemistry, Genetics and Molecular Biology
Brain Ischemia
010309 optics
Imaging, Three-Dimensional
Internal medicine
Intensive care
0103 physical sciences
Animals
Humans
Medicine
Contrast (vision)
General Materials Science
media_common
Asphyxia
business.industry
010401 analytical chemistry
General Engineering
Brain
General Chemistry
medicine.disease
0104 chemical sciences
medicine.anatomical_structure
Intraventricular hemorrhage
Cerebral blood flow
Cerebrovascular Circulation
Scalp
Cardiology
Tomography
medicine.symptom
Tomography, X-Ray Computed
business
Subjects
Details
- ISSN :
- 18640648 and 1864063X
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Journal of Biophotonics
- Accession number :
- edsair.doi.dedup.....19b0ab400ed86cd24e55b8f71e1423c4