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COVID-19 in people living with human immunodeficiency virus: A case series of 33 patients

Authors :
Stephan Grunwald
Matthias Mueller
Markus Müller
Ivanka Krznaric
Knud Schewe
Christian Hoffmann
Markus Bickel
Daniel Gillor
Georg Härter
Julia Roider
Nils Postel
Christoph D. Spinner
Katja Römer
Farhad Schabaz
Source :
Infection
Publication Year :
2020
Publisher :
Cold Spring Harbor Laboratory, 2020.

Abstract

Introduction Data on people living with human immunodeficiency virus (PLWH) in the current SARS-CoV-2 pandemic are still scarce. This case series of 33 PLWH patients with COVID-19 reveals symptoms and outcome in this special population. Methods Retrospective analysis of anonymized data including age, gender, HIV-associated parameters, symptoms, and outcome. Results Three out of 32 patients with documented outcomes died (9%). 91% of the patients recovered and 76% have been classified as mild cases. All patients were on antiretroviral treatment, of them 22 on tenofovir-containing regimen and 4 on the protease inhibitor darunavir. Conclusions This preliminary case series does not support excess morbidity and mortality among symptomatic COVID-19 PLWH and with viral suppression on ART. SARS-CoV-2 infections may occur during boosted darunavir-based and/or on tenofovir-containing ART.

Details

Database :
OpenAIRE
Journal :
Infection
Accession number :
edsair.doi.dedup.....19a761b36601a21da48c492790bafb2e