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Non-Coding RNAs as Biomarkers and Therapeutic Targets for Diabetic Kidney Disease
- Source :
- Frontiers in Pharmacology, Vol 11 (2021), Frontiers in Pharmacology
- Publication Year :
- 2021
- Publisher :
- Frontiers Media S.A., 2021.
-
Abstract
- Diabetic kidney disease (DKD) is the most common diabetic complication and is a leading cause of end-stage kidney disease. Increasing evidence shows that DKD is regulated not only by many classical signaling pathways but also by epigenetic mechanisms involving chromatin histone modifications, DNA methylation, and non-coding RNA (ncRNAs). In this review, we focus on our current understanding of the role and mechanisms of ncRNAs, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in the pathogenesis of DKD. Of them, the regulatory role of TGF-β/Smad3-dependent miRNAs and lncRNAs in DKD is highlighted. Importantly, miRNAs and lncRNAs as biomarkers and therapeutic targets for DKD are also described, and the perspective of ncRNAs as a novel therapeutic approach for combating diabetic nephropathy is also discussed.
- Subjects :
- TGF-β
Review
Disease
Bioinformatics
Diabetic nephropathy
long non-coding RNAs
microRNA
medicine
Pharmacology (medical)
Epigenetics
Pharmacology
biology
business.industry
fibrosis
lcsh:RM1-950
therapeutic target
medicine.disease
diabetic kidney disease
Chromatin
Histone
lcsh:Therapeutics. Pharmacology
micro RNAs
inflammation
DNA methylation
biology.protein
biomarker
Biomarker (medicine)
business
Subjects
Details
- Language :
- English
- ISSN :
- 16639812
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Frontiers in Pharmacology
- Accession number :
- edsair.doi.dedup.....1983160d13740b9d7e90a2e21b678ad7