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Fraxin Prevents Chemically Induced Hepatotoxicity by Reducing Oxidative Stress

Authors :
Youn-Chul Kim
Chi-Su Yoon
Bo Yoon Chang
Sung Yeon Kim
Young Suk Jung
Jae Heoi Hong
Jun Seok Oh
Source :
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry, Molecules; Volume 22; Issue 4; Pages: 587
Publication Year :
2017
Publisher :
MDPI AG, 2017.

Abstract

Fraxin isolated from Acer tegmentosum is reported to exert potent anti-oxidative stress action. However, pharmacological activities of fraxin remain to be elucidated. This study investigated the potential hepatoprotective effects of fraxin and the underlying signaling mechanism involved. Treatment with fraxin significantly lowered the serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in a CCl4-induced hepatotoxicity rat model. In the fraxin-treated group, glutathione (GSH) significantly increased, while the malondialdehyde (MDA) in the liver significantly decreased. Fraxin also showed radical-scavenging activity. Furthermore, it significantly reduced the t-BHP-induced cytotoxicity and production of reactive oxygen species (ROS) in Hep G2. Fraxin protected Hep G2 cells through Nrf2 pathway-dependent HO-1 expression. The results of this study indicate that fraxin shows potent hepatoprotective effects in vitro and in vivo, presumably through direct antioxidant activity and the Nrf2-mediated antioxidant enzyme system.

Details

ISSN :
14203049
Volume :
22
Database :
OpenAIRE
Journal :
Molecules
Accession number :
edsair.doi.dedup.....1978bf3757bfc8fec6ba80418029a617
Full Text :
https://doi.org/10.3390/molecules22040587