Back to Search
Start Over
Fraxin Prevents Chemically Induced Hepatotoxicity by Reducing Oxidative Stress
- Source :
- Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry, Molecules; Volume 22; Issue 4; Pages: 587
- Publication Year :
- 2017
- Publisher :
- MDPI AG, 2017.
-
Abstract
- Fraxin isolated from Acer tegmentosum is reported to exert potent anti-oxidative stress action. However, pharmacological activities of fraxin remain to be elucidated. This study investigated the potential hepatoprotective effects of fraxin and the underlying signaling mechanism involved. Treatment with fraxin significantly lowered the serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in a CCl4-induced hepatotoxicity rat model. In the fraxin-treated group, glutathione (GSH) significantly increased, while the malondialdehyde (MDA) in the liver significantly decreased. Fraxin also showed radical-scavenging activity. Furthermore, it significantly reduced the t-BHP-induced cytotoxicity and production of reactive oxygen species (ROS) in Hep G2. Fraxin protected Hep G2 cells through Nrf2 pathway-dependent HO-1 expression. The results of this study indicate that fraxin shows potent hepatoprotective effects in vitro and in vivo, presumably through direct antioxidant activity and the Nrf2-mediated antioxidant enzyme system.
- Subjects :
- Male
0301 basic medicine
antioxidant
Antioxidant
Biopsy
medicine.medical_treatment
Gene Expression
Pharmaceutical Science
hepatoprotective
Pharmacology
medicine.disease_cause
Antioxidants
Acer tegmentosum
Analytical Chemistry
chemistry.chemical_compound
0302 clinical medicine
A. tegmentosum
fraxin
HO-1
Nrf2
Coumarins
Drug Discovery
Carbon Tetrachloride
Chromatography, High Pressure Liquid
chemistry.chemical_classification
biology
Hep G2 Cells
Malondialdehyde
Hep G2
Biochemistry
Chemistry (miscellaneous)
030220 oncology & carcinogenesis
Molecular Medicine
Chemical and Drug Induced Liver Injury
Oxidation-Reduction
Cell Survival
NF-E2-Related Factor 2
Article
03 medical and health sciences
medicine
Animals
Humans
Physical and Theoretical Chemistry
Reactive oxygen species
Plant Extracts
Organic Chemistry
Glutathione
biology.organism_classification
Rats
Disease Models, Animal
Oxidative Stress
030104 developmental biology
chemistry
Fraxin
Reactive Oxygen Species
Heme Oxygenase-1
Oxidative stress
Subjects
Details
- ISSN :
- 14203049
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....1978bf3757bfc8fec6ba80418029a617
- Full Text :
- https://doi.org/10.3390/molecules22040587