Back to Search
Start Over
Evaluation of an alternative dosing regimenwith tadalafil, three times per week, for men with erectile dysfunction: SURE study in Italy
- Publication Year :
- 2007
-
Abstract
- AIM: To examine the preference for two dosing regimens of 20 mg of tadalafil, on demand or three times per week, in men affected with erectile dysfunction (ED) in Italy. METHODS: Scheduled Use versus on demand Regimen Evaluation (SURE) is a multicenter, crossover and open-label study, involving 94 urology centers in Italy. Patients aged 18 years or older affected with ED for at least 3 months were enrolled and randomized to 20 mg of tadalafil treatment on demand or three times per week for 5-6 weeks. After a 1-week washout, patients were crossed over to the alternate regimen for 5-6 weeks. A treatment preference question was used to determine the preferred treatment regimen. International Index of Erectile Function (IIEF) and Sexual Encounter Profile (SEP) questionnaire were used as efficacy measures. RESULTS: A total of 1 058 men (mean age 54.8 years), were randomized to treatment. Overall, 59.1% of patients preferred the on-demand regimen and 41.9% preferred the three times per week dosing. Both regimens were efficacious and well tolerated. Although a statistically higher improvement of the IIEF erectile function (IIEF-EF) domain score and the SEP questionnaire was reported for the three times per week compared to the on-demand treatment regimen, this difference was numerically minimal and lacking in clinical significance. CONCLUSION: Tadalafil is effective and well tolerated whether used on demand or three times per week. Patients should be given the option to choose the best treatment regimen according to personal needs and preferences.
- Subjects :
- Male
medicine.medical_specialty
Alternate
Erectile dysfunction
On demand
SURE study
Tadalafil
Three times per week
Carbolines
Cross-Over Studies
Drug Administration Schedule
Erectile Dysfunction
Humans
Italy
Middle Aged
Phosphodiesterase Inhibitors
Treatment Outcome
Nephrology
Endocrinology
erectile dysfunction
Urology
on demand
three times per week
alternate
tadalafil
law.invention
Settore MED/24 - Urologia
Randomized controlled trial
law
Internal medicine
Medicine
Clinical significance
Dosing
Erectile dysfunction, SURE Study, on demand, three times per week, alternate, tadalafil
business.industry
General Medicine
medicine.disease
Crossover study
Surgery
Regimen
business
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....1954e93171113b962be2bdcf0d37d0fe