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Streptozotocin-induced diabetes in the pregnant rat reduces 11 beta-hydroxysteroid dehydrogenase type 2 expression in placenta and fetal kidney
- Source :
- Life sciences. 75(23)
- Publication Year :
- 2004
-
Abstract
- Several epidemiological and animal studies have shown that the offsprings of diabetic mothers have higher incidences of glucose intolerance, obesity, insulin resistance, and hypertension in later life. It is well known that glucocorticoid metabolism plays a crucial role on several adult disease originated from fetal environment. The aim of this study was to investigate the relation between diabetic pregnancy and glucocorticoid metabolism of both mother and fetus, focusing on the 11 beta-hydroxysteroid dehydrogenase (11beta-HSD) type 2. A model of diabetic pregnancy was made by intravenous injection of streptozotocin (35 mg/kg body weight) to Sprague-Dawley rats, and blood and tissue samples were collected on day 20 of pregnancy. In the diabetic group, expression of 11 beta-hydroxysteroid dehydrogenase type 2 in placentas and fetal kidneys was decreased remarkably. Corticosterone levels of diabetic mothers were lower than those of control rats. Despite the differences in maternal corticosterone levels, fetal levels of corticosterone did not differ between the groups. Our results lend support to the concept that diabetic pregnancy imprints glucocorticoid regulation in these fetuses, which may contribute to their increased incidence of higher blood pressure as adults.
- Subjects :
- Blood Glucose
medicine.medical_specialty
DNA, Complementary
Litter Size
Placenta
Biology
Kidney
General Biochemistry, Genetics and Molecular Biology
Fetal Kidney
Diabetes Mellitus, Experimental
Insulin resistance
Fetus
Pregnancy
Diabetes mellitus
Internal medicine
11-beta-Hydroxysteroid Dehydrogenase Type 2
medicine
Animals
General Pharmacology, Toxicology and Pharmaceutics
C-Peptide
Body Weight
Kidney metabolism
General Medicine
medicine.disease
Streptozotocin
Blotting, Northern
Rats
Endocrinology
Gene Expression Regulation
Female
Corticosterone
Glucocorticoid
medicine.drug
Subjects
Details
- ISSN :
- 00243205
- Volume :
- 75
- Issue :
- 23
- Database :
- OpenAIRE
- Journal :
- Life sciences
- Accession number :
- edsair.doi.dedup.....195360e6c492dddd864f3813de591c04