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Late Complications and Quality of Life after Reduced-Intensity Conditioning Allogeneic Stem Cell Transplantation
- Source :
- Biology of Blood and Marrow Transplantation, Biology of Blood and Marrow Transplantation, 2016, 23 (1), pp.140-146. ⟨10.1016/j.bbmt.2016.10.011⟩, Biology of Blood and Marrow Transplantation, Elsevier, 2016, 23 (1), pp.140-146. ⟨10.1016/j.bbmt.2016.10.011⟩
- Publication Year :
- 2016
- Publisher :
- HAL CCSD, 2016.
-
Abstract
- International audience; Late complications (LC) and quality of life (QOL) were analyzed in 110 adult patients who underwent reduced-intensity conditioning (RIC) allogeneic stem cell transplantation (allo-SCT) and were alive for more than 2 years after allo-SCT. Overall survival of these patients was 93% (95% confidence interval [CI], 88% to 99%) and 81% (95% CI, 71% to 94%) at 5 and 10 years, respectively. The primary cause of death was a recurrence of primary malignancy. With a median follow-up of 4.6 years (range, 2 to 12.1), chronic graft-versus-host disease (cGVHD) was the most prevalent late effect, with a cumulative incidence of 66% (95% CI, 57% to 74%) at 10 years. Car-diovascular complications were the most prevalent LC with a cumulative incidence of 47% (95% CI, 35% to 59%), followed by pulmonary complications with a cumulative incidence of 33% (95% CI, 21% to 46%) and renal impairment with a cumulative incidence of 34% (95% CI, 25% to 43%) at 10 years. Secondary malignancies occurred with a cumulative incidence of 11% (95% CI, 5% to 20%) at 10 years. In this series, 61 patients (55%) responded to QOL survey. With the use of European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire–Core 30 and Functional Assessment of Cancer Therapy–Bone Marrow Transplant questionnaires , most of the patients reported good to excellent QOL and patients with cGVHD had significantly lower QOL than patients without cGVHD. In conclusion, QOL after RIC is comparable to that seen after myeloablative conditioning, while the natural history of LC after RIC appears to be different from that described in the standard myeloablative setting, warranting further research in this field.
- Subjects :
- Adult
Lung Diseases
Male
Quality of life
medicine.medical_specialty
Transplantation Conditioning
Graft vs Host Disease
[SDV.CAN]Life Sciences [q-bio]/Cancer
Young Adult
03 medical and health sciences
0302 clinical medicine
conditioning
[SDV.CAN] Life Sciences [q-bio]/Cancer
Surveys and Questionnaires
Internal medicine
medicine
Humans
Transplantation, Homologous
Cumulative incidence
Survivors
Aged
Cause of death
Reduced-intensity
Transplantation
business.industry
Hematopoietic Stem Cell Transplantation
Late effect
Cancer
Neoplasms, Second Primary
Hematology
Middle Aged
medicine.disease
Confidence interval
3. Good health
Surgery
Natural history
Cardiovascular Diseases
030220 oncology & carcinogenesis
Long-term effects
medicine.symptom
Reduced-intensity conditioning
business
Follow-Up Studies
030215 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 10838791 and 15236536
- Database :
- OpenAIRE
- Journal :
- Biology of Blood and Marrow Transplantation, Biology of Blood and Marrow Transplantation, 2016, 23 (1), pp.140-146. ⟨10.1016/j.bbmt.2016.10.011⟩, Biology of Blood and Marrow Transplantation, Elsevier, 2016, 23 (1), pp.140-146. ⟨10.1016/j.bbmt.2016.10.011⟩
- Accession number :
- edsair.doi.dedup.....194c994354fedff257c29cead0c25cd5