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Stability and similarity of the pediatric connectome as developmental measures
- Source :
- NeuroImage, Vol 226, Iss, Pp 117537-(2021)
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- Patterns of functional connectivity are unique at the individual level, enabling test-retest matching algorithms to identify a subject from among a group using only their functional connectome. Recent findings show that accuracies of these algorithms in children increase with age. Relatedly, the persistence of functional connectivity (FC) patterns across tasks and rest also increases with age. This study investigated the hypothesis that within-subject stability and between-subject similarity of the whole-brain pediatric connectome are developmentally relevant outcomes. Using data from 210 help-seeking children and adolescents, ages 6–21 years (Healthy Brain Network Biobank), we computed whole-brain FC matrices for each participant during two different movies (MovieDM and MovieTP) and two runs of task-free rest (all from a single scan session) and fed these matrices to a test-retest matching algorithm. We replicated the finding that matching accuracies for children and youth (ages 6–21 years) are low (18–44%), and that cross-state and cross-movie accuracies were the lowest. Results also showed that parcellation resolution and the number of volumes used in each matrix affect fingerprinting accuracies. Next, we calculated three measures of whole-connectome stability for each subject: cross-rest (Rest1-Rest2), cross-state (MovieDM-Rest1), and cross-movie (MovieDM-MovieTP), and three measures of within-state between-subject connectome similarity for Rest1, MovieDM, and MovieTP. We show that stability and similarity were correlated, but that these measures were not related to age. A principal component analysis of these measures yielded two components that we used to test for brain-behavior correlations with IQ, general psychopathology, and social skills measures (n = 119). The first component was significantly correlated with the social skills measure (r=-0.26, p = 0.005). Post hoc correlations showed that the social skills measure correlated with both cross-rest stability (r=-0.29, p = 0.001) and with connectome similarity during MovieDM (r=-0.28, p = 0.002). These findings suggest that the stability and similarity of the whole-brain connectome relate to the development of social skills. We infer that the maturation of the functional connectome simultaneously achieves patterns of FC that are distinct at the individual subject level, that are shared across individuals, and that are persistent across states and across runs—features which presumably combine to optimize neural processing during development. Future longitudinal work could reveal the developmental trajectories of stability and similarity of the connectome.
- Subjects :
- Male
Matching (statistics)
Adolescent
Cognitive Neuroscience
Stability (learning theory)
Development
Affect (psychology)
050105 experimental psychology
lcsh:RC321-571
Social Skills
Social skills, fMRI
Young Adult
03 medical and health sciences
Functional connectivity
Child Development
0302 clinical medicine
Similarity (network science)
Social skills
Statistics
Connectome
Humans
0501 psychology and cognitive sciences
Child
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
Movies
05 social sciences
Brain
Reproducibility of Results
Magnetic Resonance Imaging
Naturalistic
Neurology
Principal component analysis
Female
Nerve Net
Psychology
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 10959572
- Volume :
- 226
- Database :
- OpenAIRE
- Journal :
- NeuroImage
- Accession number :
- edsair.doi.dedup.....194b97252114810777eb931cd330175a