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Autoantibodies to the insulin receptor impair clearance of plasma endogenous insulin
- Source :
- Diabetes Research and Clinical Practice. 7:S41-S44
- Publication Year :
- 1989
- Publisher :
- Elsevier BV, 1989.
-
Abstract
- Plasma insulin clearnce was studied in a patient with autoantibodies to the insulin receptor, manifesting persistent hyperinsulinemia associated with alternating hyper- and hypoglycemia. In the postabsorptive period, the plasma glucose level gradually decreased. To prevent the development of hypoglycemia, glucose was infused and the glycemic level was clamped at 50 mg/dl without insulin infusion. The plasma C-peptide level was below the detectable range during the clamp, indicating no appreciable secretion of insulin. The plasma insulin level declined exponentially with a markedly prolonged disappearance rate (half-time: 3.0 h) during the study. These results indicate that hyperinsulinemia in the postabsorptive period in this patient is attributable to the impairment of plasma insulin clearance through receptor-mediated mechanisms, and also confirm that the receptor plays the principal role in plasma insulin removal.
- Subjects :
- Blood Glucose
Male
medicine.medical_specialty
Metabolic Clearance Rate
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Hypoglycemia
Endocrinology
Internal medicine
Diabetes mellitus
Internal Medicine
medicine
Hyperinsulinemia
Humans
Insulin
Acanthosis Nigricans
Receptor
Autoantibodies
Glycemic
biology
business.industry
General Medicine
Middle Aged
medicine.disease
Receptor, Insulin
Insulin oscillation
Insulin receptor
Glucose Clamp Technique
biology.protein
business
Subjects
Details
- ISSN :
- 01688227
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Diabetes Research and Clinical Practice
- Accession number :
- edsair.doi.dedup.....19400c702cc913b7e7e4986676885c8d