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KIR+CD8+ T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19
- Source :
- Science (New York, N.Y.), vol 376, iss 6590
- Publication Year :
- 2022
- Publisher :
- eScholarship, University of California, 2022.
-
Abstract
- In this work, we find that CD8 + T cells expressing inhibitory killer cell immunoglobulin-like receptors (KIRs) are the human equivalent of Ly49 + CD8 + regulatory T cells in mice and are increased in the blood and inflamed tissues of patients with a variety of autoimmune diseases. Moreover, these CD8 + T cells efficiently eliminated pathogenic gliadin-specific CD4 + T cells from the leukocytes of celiac disease patients in vitro. We also find elevated levels of KIR + CD8 + T cells, but not CD4 + regulatory T cells, in COVID-19 patients, correlating with disease severity and vasculitis. Selective ablation of Ly49 + CD8 + T cells in virus-infected mice led to autoimmunity after infection. Our results indicate that in both species, these regulatory CD8 + T cells act specifically to suppress pathogenic T cells in autoimmune and infectious diseases.
Details
- ISSN :
- 00368075
- Database :
- OpenAIRE
- Journal :
- Science (New York, N.Y.), vol 376, iss 6590
- Accession number :
- edsair.doi.dedup.....193563d69927496f79c565b0e039e25a