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Folic acid and vitamin B12 are more effective than vitamin B6 in lowering fasting plasma homocysteine concentration in patients with coronary artery disease
- Source :
- European Journal of Clinical Nutrition. 58:481-487
- Publication Year :
- 2004
- Publisher :
- Springer Science and Business Media LLC, 2004.
-
Abstract
- Objective: To investigate whether vitamin B6 supplementation had a beneficial effect on lowering fasting plasma homocysteine concentrations in coronary artery disease (CAD) patients. Design: A single-blind intervention study. Setting: The study was performed at the Taichung Veterans General Hospital, the central part of Taiwan. Subjects: A total of 50 subjects were identified by cardiac catheterization to have at least 70% stenosis of one major coronary artery. In all, 42 patients successfully completed this study. Interventions: Patients were randomly assigned to one of five groups and treated with a daily dose of placebo (n=8), 5 mg vitamin B6 (n=8), 10 mg vitamin B6 (n=8), 50 mg vitamin B6 (n=9), or 5 mg folic acid combined with 0.25 mg vitamin B12 (n=9) for 12 weeks. Main outcome measures: Nutrient intakes were recorded by using 24-h diet recalls when patients returned to the cardiology clinic before the intervention (week 0) and at week 12. Vitamin B6 status was assessed by direct measures (plasma pyridoxal 5′-phosphate) and indirect measures (erythrocyte alanine and aspartate aminotransaminase activity coefficient). Fasting plasma homocysteine, serum folic acid, and vitamin B12 were measured. Results: Fasting plasma homocysteine concentration did not respond to high or low doses of vitamin B6 when compared with a placebo treatment after 12 weeks of supplementation. The mean fasting plasma homocysteine concentration, however, decreased significantly after 12 weeks of folic acid combined with vitamin B12 supplementation (P=0.047). Further, within group, mean fasting plasma homocysteine concentration was nonsignificantly increased by 25.5, 16.2, and 18.3% in placebo, 10 mg/day and 50 mg/day vitamin B6 supplemented groups, respectively; whereas folic acid combined with vitamin B12 supplementation significantly reduced fasting plasma homocysteine concentration by 32% (P
- Subjects :
- Adult
Male
medicine.medical_specialty
Homocysteine
Medicine (miscellaneous)
Coronary Artery Disease
Placebo
chemistry.chemical_compound
Folic Acid
Internal medicine
Blood plasma
medicine
Humans
Single-Blind Method
Vitamin B12
Cyanocobalamin
Pyridoxal
Aged
Aged, 80 and over
Nutrition and Dietetics
Dose-Response Relationship, Drug
business.industry
Retinol
Middle Aged
Vitamin B 6
Vitamin B 12
B vitamins
Treatment Outcome
Endocrinology
chemistry
Mental Recall
Female
business
Subjects
Details
- ISSN :
- 14765640 and 09543007
- Volume :
- 58
- Database :
- OpenAIRE
- Journal :
- European Journal of Clinical Nutrition
- Accession number :
- edsair.doi.dedup.....19275c93205aed176d38a58ee868e5f5