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Chronic lung inflammation primes humoral immunity and augments antipneumococcal resistance
- Source :
- Scientific Reports, Scientific reports, Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- Airway epithelial cells (AECs) display remarkable plasticity in response to infectious stimuli and their functional adaptations are critical for antimicrobial immunity. However, the roles of AECs and humoral mediators to host defense in non-communicable lung inflammation remain elusive. We dissected pulmonary defense against Streptococcus pneumoniae in hosts with pre-existing inflammatory conditions (SPC-HAxTCR-HA mice). Lung tissue transcriptomics and bronchoalveolar lavage fluid (BALF) proteomics revealed an induction of humoral defense mechanisms in inflamed lungs. Accordingly, besides antibacterial proteins and complement components being overrepresented in inflamed lungs, elevated polymeric immunoglobulin receptor (pIgR)-expression in AECs correlated with increased secretory immunoglobulin (SIg) transport. Consequently, opsonization assays revealed augmented pneumococcal coverage by SIgs present in the BALF of SPC-HAxTCR-HA mice, which was associated with enhanced antipneumococcal resistance. These findings emphasize the immunologic potential of AECs as well as their central role in providing antibacterial protection and put forward pIgR as potential target for therapeutic manipulation in infection-prone individuals.
- Subjects :
- Proteomics
0301 basic medicine
Immunoglobulin A
Science
Inflammation
Article
Mice
03 medical and health sciences
Immunity
medicine
Animals
Oligonucleotide Array Sequence Analysis
Multidisciplinary
medicine.diagnostic_test
biology
Sequence Analysis, RNA
Gene Expression Profiling
Receptors, Polymeric Immunoglobulin
Pneumonia
respiratory system
respiratory tract diseases
Antibody opsonization
Disease Models, Animal
Streptococcus pneumoniae
030104 developmental biology
Bronchoalveolar lavage
Immunoglobulin A, Secretory
Humoral immunity
Immunology
biology.protein
Medicine
medicine.symptom
Antibody
Polymeric immunoglobulin receptor
Bronchoalveolar Lavage Fluid
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....191d6be3ebe15e27326d0ecb74322793