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Interleukin induction of non-specific suppressor cells
- Source :
- Annales de l'Institut Pasteur / Immunologie. 137:3-10
- Publication Year :
- 1986
- Publisher :
- Elsevier BV, 1986.
-
Abstract
- We analysed the cellular and molecular signals involved in the induction of non-specific T suppressor (Ts) cells generated in mouse spleen cell suspensions after 3-4 days' culture in the absence of conventional antigen. Using an in vitro model of primary antibody response as a suppressor assay, we showed that purified T cells were unable to generate suppressive activity. This suppression was fully restored when T cells were cultured with macrophages. In this case, Ts-cell generation was markedly increased by the addition of indomethacin suggesting a negative effect of prostaglandins in this phenomenon. Macrophages could be replaced by semi-purified IL1 as well as by recombinant IL2. Thus, in conditions of severe macrophage depletion, IL1 and/or IL2 are fully capable of inducing Ts-cell generation.
- Subjects :
- musculoskeletal diseases
Interleukin 2
medicine.medical_specialty
T-Lymphocytes
Indomethacin
Biology
T-Lymphocytes, Regulatory
Mice
Antigen
Internal medicine
medicine
Animals
Humans
Macrophage
Cells, Cultured
General Environmental Science
Immunosuppression Therapy
Macrophages
Lymphokine
Interleukin
General Medicine
T lymphocyte
Molecular biology
Endocrinology
Mice, Inbred DBA
Cell culture
Antibody Formation
Myeloid-derived Suppressor Cell
Interleukin-2
General Earth and Planetary Sciences
Spleen
Interleukin-1
medicine.drug
Subjects
Details
- ISSN :
- 07692625
- Volume :
- 137
- Database :
- OpenAIRE
- Journal :
- Annales de l'Institut Pasteur / Immunologie
- Accession number :
- edsair.doi.dedup.....19165b8046223e007ed3323e165aece8