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Effects of a Senso (Toad Venom) Containing Drug on Systemic Hemodynamics, Cardiac Function and Myocadial Oxygen Consumption in Anesthetized Dogs
- Source :
- The American Journal of Chinese Medicine. 19:17-31
- Publication Year :
- 1991
- Publisher :
- World Scientific Pub Co Pte Lt, 1991.
-
Abstract
- Effects of a Senso (toad venom)-containing drug, KY, on cardiovascular system were examined in anesthetized open-chest dogs. KY increased aortic pressure, peak positive first derivative of left ventricular pressure, stroke work index, percent segment shortening in left ventricular myocardium and myocardial oxygen consumption, and decreased heart rate and total peripheral vascular resistance (TPR). Propranolol augmented the increase in aortic pressure with KY, inhibited the increase in aortic flow with KY and reversed KY-induced decrease in TPR to an increase. These results indicate that KY has positive inotropic and vasodilating actions possibly originating from both digitalis- and adrenaline-like action of a Senso.
- Subjects :
- Cardiac function curve
Inotrope
medicine.medical_specialty
Hemodynamics
Vasodilation
Propranolol
Biology
Electrocardiography
Dogs
Oxygen Consumption
Internal medicine
medicine
Animals
Medicine, Chinese Traditional
Infusions, Intravenous
Ouabain
Dose-Response Relationship, Drug
Myocardium
Isoproterenol
Heart
General Medicine
Myocardial Contraction
Stimulation, Chemical
Endocrinology
medicine.anatomical_structure
Complementary and alternative medicine
Amphibian Venoms
cardiovascular system
Aortic pressure
Cardiology
Ventricular pressure
Vascular resistance
medicine.drug
Subjects
Details
- ISSN :
- 17936853 and 0192415X
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- The American Journal of Chinese Medicine
- Accession number :
- edsair.doi.dedup.....1902176ab93b3b0782af1822bab3caa9