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Preexisting melanoma and hematological malignancies, prognosis, and timing to solid organ transplantation: A consensus expert opinion statement

Authors :
Piyush K. Agarwal
Kymberly D. Watt
Alexander S. Krupnick
Fiona Zwald
Didier A. Mandelbrot
John Walker
John Richgels
Carrie L. Langstraat
Deborah Levine
Thomas M. Habermann
Jayme E. Locke
Don S. Dizon
Nisha Mohindra
Cristina B. Geltzeiler
Laura L. Hammel
E. Steve Woodle
David P. Foley
Rocco Ricciardi
Cassie C. Kennedy
Richard D. Carvajal
George J. Chang
Jennifer K. Plichta
Scott E. Eggener
Talal Al-Qaoud
David P. Al-Adra
Deborah Farr
Jonathan D'Cunha
Morie A. Gertz
John P. Roberts
Deirdre Sawinski
Sandhya Pruthi
Elizabeth C. Verna
Maryjane Farr
Gonzalo Sapisochin
Philip J. Bierman
Source :
American Journal of Transplantation. 21:475-483
Publication Year :
2021
Publisher :
Elsevier BV, 2021.

Abstract

Patients undergoing evaluation for solid organ transplantation (SOT) frequently have a history of malignancy. Only patients with treated cancer are considered for SOT but the benefits of transplantation need to be balanced against the risk of tumor recurrence, taking into consideration the potential effects of immunosuppression. Prior guidelines on timing to transplant in patients with a prior treated malignancy do not account for current staging, disease biology, or advances in cancer treatments. To update these recommendations, the American Society of Transplantation (AST) facilitated a consensus workshop to comprehensively review contemporary literature regarding cancer therapies, cancer stage specific prognosis, the kinetics of cancer recurrence, as well as the limited data on the effects of immunosuppression on cancer-specific outcomes. This document contains prognosis, treatment, and transplant recommendations for melanoma and hematological malignancies. Given the limited data regarding the risk of cancer recurrence in transplant recipients, the goal of the AST-sponsored conference and the consensus documents produced are to provide expert opinion recommendations that help in the evaluation of patients with a history of a pretransplant malignancy for transplant candidacy.

Details

ISSN :
16006135
Volume :
21
Database :
OpenAIRE
Journal :
American Journal of Transplantation
Accession number :
edsair.doi.dedup.....18f94a083b931af6d6efacc958982b77