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Comparison of the Incorporation of DHA in Circulatory and Neural Tissue When Provided as Triacylglycerol (TAG), Monoacylglycerol (MAG) or Phospholipids (PL) Provides New Insight into Fatty Acid Bioavailability
- Source :
- Nutrients, Nutrients; Volume 10; Issue 5; Pages: 620
- Publication Year :
- 2018
- Publisher :
- MDPI AG, 2018.
-
Abstract
- Phospholipids (PL) or partial acylglycerols such as sn-1(3)-monoacylglycerol (MAG) are potent dietary carriers of long-chain polyunsaturated fatty acids (LC-PUFA) and have been reported to provide superior bioavailability when compared to conventional triacylglycerol (TAG). The main objective of the present study was to compare the incorporation of docosahexaenoic acid (DHA) in plasma, erythrocytes, retina and brain tissues in adult rats when provided as PL (PL-DHA) and MAG (MAG-DHA). Conventional dietary DHA oil containing TAG (TAG-DHA) as well as control chow diet were used to evaluate the potency of the two alternative DHA carriers over a 60-day feeding period. Fatty acid profiles were determined in erythrocytes and plasma lipids at time 0, 7, 14, 28, 35 and 49 days of the experimental period and in retina, cortex, hypothalamus, and hippocampus at 60 days. The assessment of the longitudinal evolution of DHA in erythrocyte and plasma lipids suggest that PL-DHA and MAG-DHA are efficient carriers of dietary DHA when compared to conventional DHA oil (TAG-DHA). Under these experimental conditions, both PL-DHA and MAG-DHA led to higher incorporations of DHA erythrocytes lipids compared to TAG-DHA group. After 60 days of supplementation, statistically significant increase in DHA level incorporated in neural tissues analyzed were observed in the DHA groups compared with the control. The mechanism explaining hypothetically the difference observed in circulatory lipids is discussed.
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
Erythrocytes
Docosahexaenoic Acids
genetic structures
sn-1(3)-monoacylglycerol
Glyceride
Biological Availability
Weight Gain
Article
long-chain polyunsaturated fatty acids
03 medical and health sciences
Internal medicine
medicine
Animals
Sunflower Oil
Potency
Rats, Wistar
Triglycerides
phospholipids
chemistry.chemical_classification
030109 nutrition & dietetics
Nutrition and Dietetics
Fatty Acids
food and beverages
Fatty acid
docosahexaenoic acid
Dietary Fats
Diet
Rats
Soybean Oil
Bioavailability
Monoacylglycerol lipase
030104 developmental biology
Endocrinology
Eicosapentaenoic Acid
chemistry
Docosahexaenoic acid
Hypothalamus
Sample Size
triacylglycerol
Body Composition
Monoglycerides
lipids (amino acids, peptides, and proteins)
Food Science
Polyunsaturated fatty acid
Subjects
Details
- ISSN :
- 20726643
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....18f3cd01230725daf6b6691a501118d9