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Under the Radar: Epidemiology of Plasmodium ovale in the Democratic Republic of the Congo
- Source :
- J Infect Dis
- Publication Year :
- 2020
- Publisher :
- Oxford University Press (OUP), 2020.
-
Abstract
- Background Plasmodium ovale is an understudied malaria species prevalent throughout much of sub-Saharan Africa. Little is known about the distribution of ovale malaria and risk factors for infection in areas of high malaria endemicity. Methods Using the 2013 Democratic Republic of the Congo (DRC) Demographic and Health Survey, we conducted a risk factor analysis for P. ovale infections. We evaluated geographic clustering of infections and speciated to P. ovale curtisi and P. ovale wallikeri through deep sequencing. Results Of 18 149 adults tested, we detected 143 prevalent P. ovale infections (prevalence estimate 0.8%; 95% confidence interval [CI], .59%–.98%). Prevalence ratios (PR) for significant risk factors were: male sex PR = 2.12 (95% CI, 1.38–3.26), coprevalent P. falciparum PR = 3.52 (95% CI, 2.06–5.99), and rural residence PR = 2.19 (95% CI, 1.31–3.66). P. ovale was broadly distributed throughout the DRC; an elevated cluster of infections was detected in the south-central region. Speciation revealed P. ovale curtisi and P. ovale wallikeri circulating throughout the country. Conclusions P. ovale persists broadly in the DRC, a high malaria burden country. For successful elimination of all malaria species, P. ovale needs to be on the radar of malaria control programs.
- Subjects :
- Adult
0301 basic medicine
medicine.medical_specialty
Plasmodium ovale
030231 tropical medicine
Prevalence
Disease cluster
digestive system
Major Articles and Brief Reports
03 medical and health sciences
0302 clinical medicine
stomatognathic system
parasitic diseases
Epidemiology
medicine
Humans
Immunology and Allergy
Risk factor
biology
business.industry
digestive, oral, and skin physiology
Plasmodium falciparum
medicine.disease
biology.organism_classification
Malaria
030104 developmental biology
Infectious Diseases
Democratic Republic of the Congo
business
Ovale malaria
Demography
Subjects
Details
- ISSN :
- 15376613 and 00221899
- Volume :
- 223
- Database :
- OpenAIRE
- Journal :
- The Journal of Infectious Diseases
- Accession number :
- edsair.doi.dedup.....18f230efd39d358c9c23ec5a9104597b