Back to Search
Start Over
Role of galectin 3 binding protein in cancer progression: a potential novel therapeutic target
- Source :
- Journal of Translational Medicine, Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-18 (2021)
- Publication Year :
- 2021
- Publisher :
- BioMed Central, 2021.
-
Abstract
- The lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a secreted, hyperglycosylated protein expressed by the majority of human cells. It was first identified as cancer and metastasis associated protein, while its role in innate immune response upon viral infection remains still to be clarified. Since its discovery dated in early 90 s, a large body of literature has been accumulating highlighting both a prognostic and functional role for LGALS3BP in cancer. Moreover, data from our group and other have strongly suggested that this protein is enriched in cancer-associated extracellular vesicles and may be considered a promising candidate for a targeted therapy in LGALS3BP positive cancers. Here, we extensively reviewed the literature relative to LGALS3BP role in cancer and its potential value as a therapeutic target.
- Subjects :
- Galectin 3 binding protein
medicine.medical_treatment
Galectin 3
Review
Extracellular vesicles
General Biochemistry, Genetics and Molecular Biology
Targeted therapy
Metastasis
Antigens, Neoplasm
Cell Line, Tumor
Neoplasms
medicine
Biomarkers, Tumor
Humans
Glycoproteins
Innate immune system
biology
Binding protein
Cancer
Lectin
General Medicine
medicine.disease
Prognosis
Cancer research
biology.protein
Medicine
Carrier Proteins
Subjects
Details
- Language :
- English
- ISSN :
- 14795876
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Journal of Translational Medicine
- Accession number :
- edsair.doi.dedup.....18f162a70bc72548daa76f21ac6788ce