Back to Search Start Over

Role of galectin 3 binding protein in cancer progression: a potential novel therapeutic target

Authors :
Stefano Iacobelli
Gianluca Sala
Emily Capone
Source :
Journal of Translational Medicine, Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-18 (2021)
Publication Year :
2021
Publisher :
BioMed Central, 2021.

Abstract

The lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a secreted, hyperglycosylated protein expressed by the majority of human cells. It was first identified as cancer and metastasis associated protein, while its role in innate immune response upon viral infection remains still to be clarified. Since its discovery dated in early 90 s, a large body of literature has been accumulating highlighting both a prognostic and functional role for LGALS3BP in cancer. Moreover, data from our group and other have strongly suggested that this protein is enriched in cancer-associated extracellular vesicles and may be considered a promising candidate for a targeted therapy in LGALS3BP positive cancers. Here, we extensively reviewed the literature relative to LGALS3BP role in cancer and its potential value as a therapeutic target.

Details

Language :
English
ISSN :
14795876
Volume :
19
Database :
OpenAIRE
Journal :
Journal of Translational Medicine
Accession number :
edsair.doi.dedup.....18f162a70bc72548daa76f21ac6788ce