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Lack of modifying effects of genistein on disruption of the reproductive system by perinatal dietary exposure to ethinylestradiol in rats
- Source :
- Reproductive toxicology (Elmsford, N.Y.). 18(5)
- Publication Year :
- 2003
-
Abstract
- We previously found that effects of perinatal dietary exposure to ethinylestradiol (EE) on the rat reproductive system differ depending on the diet used, with a more pronounced estrogenic impact with a regular diet that includes soy-derived proteins than with a soy-free (SF) diet. The present study was performed to examine whether genistein (GEN), a soy-derived major phytoestrogen, acts synergistically with EE. Maternal rats were fed SF diet without chemical (control) or containing 0.5-ppm EE, 0.5-ppm EE + 100-ppm GEN, 0.5-ppm EE + 1250-ppm GEN, or 1250-ppm GEN, from gestational day 15 to postnatal day (PND) 11. EE reduced serum testosterone in males at PND 3, and affected the onset of puberty of both sexes and estrous cyclicity and reproductive system in females, irrespective of co-administration of GEN. GEN alone also affected estrous cyclicity and the reproductive system in females. However, no combination effects of GEN with EE were evident, suggesting no synergism between the two.
- Subjects :
- Male
medicine.medical_specialty
Sex Differentiation
Litter Size
medicine.drug_class
media_common.quotation_subject
Genistein
Administration, Oral
Estrous Cycle
Phytoestrogens
Biology
Toxicology
Ethinyl Estradiol
chemistry.chemical_compound
Oral administration
Pregnancy
Internal medicine
Ethinylestradiol
Adrenal Glands
Testis
medicine
Animals
Testosterone
Reproductive system
media_common
Estrous cycle
Epididymis
Reproduction
Body Weight
Ovary
Uterus
Estrogens
Rats, Inbred Strains
Rats
Endocrinology
chemistry
Estrogen
Pituitary Gland
Prenatal Exposure Delayed Effects
Gestation
Female
medicine.drug
Subjects
Details
- ISSN :
- 08906238
- Volume :
- 18
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Reproductive toxicology (Elmsford, N.Y.)
- Accession number :
- edsair.doi.dedup.....18e1d260ac13284090edd33fb1030d72