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Leptin resistance elicits depressive-like behaviors in rats
- Source :
- Brain, behavior, and immunity. 60
- Publication Year :
- 2016
-
Abstract
- There is a growing appreciation that the complications of obesity extend to the central nervous system (CNS) and include increased risk for development of neuropsychiatric co-morbidities such as depressive illness. The neurological consequences of obesity may develop as a continuum and involve a progression of pathological features which is initiated by leptin resistance. Leptin resistance is a hallmark feature of obesity, but it is unknown whether leptin resistance or blockage of leptin action is casually linked to the neurological changes which underlie depressive-like phenotypes. Accordingly, the aim of the current study was to examine whether chronic administration of a pegylated leptin receptor antagonist (Peg-LRA) elicits depressive-like behaviors in adult male rats. Peg-LRA administration resulted in endocrine and metabolic features that are characteristic of an obesity phenotype. Peg-LRA rats also exhibited increased immobility in the forced swim test, depressive-like behaviors that were accompanied by indices of peripheral inflammation. These results demonstrate that leptin resistance elicits an obesity phenotype that is characterized by peripheral immune changes and depressive-like behaviors in rats, supporting the concept that co-morbid obesity and depressive illness develop as a continuum resulting from changes in the peripheral endocrine and metabolic milieu.
- Subjects :
- 0301 basic medicine
Leptin
Male
medicine.medical_specialty
Immunology
Central nervous system
Inflammation
Rats, Sprague-Dawley
03 medical and health sciences
Behavioral Neuroscience
0302 clinical medicine
Immune system
Internal medicine
Medicine
Endocrine system
Animals
Obesity
Leptin receptor
Behavior, Animal
Endocrine and Autonomic Systems
business.industry
Depression
Body Weight
medicine.disease
030104 developmental biology
medicine.anatomical_structure
Endocrinology
medicine.symptom
business
030217 neurology & neurosurgery
Behavioural despair test
Subjects
Details
- ISSN :
- 10902139
- Volume :
- 60
- Database :
- OpenAIRE
- Journal :
- Brain, behavior, and immunity
- Accession number :
- edsair.doi.dedup.....18d6924f9dec4ec66f94360306bfbcd4