Mechanoregulation of cortical bone after implant insertion from Mechanical regulation of bone formation and resorption around implants in a mouse model of osteopenic bone

Figure S1. (a) Changes in cortical thickness (Ct.Th) away from the implantation site in control (CTR) and loaded (CML) mice. # denotes a significant difference (p < 0.05) before and after loading within the same group. * denotes a significant difference (p < 0.05) between groups within the same time point. Data reported as mean value with standard error. (b-e) Frequency distributions of tissue microstrains in formation and resorption regions of cortical bone far from the implant. Data calculated (b) after implant insertion at week-interval (w-i) 1.5 and (c) following 2 weeks of cyclic mechanical loading (w-i 5). Corresponding (re)modeling rules describing the probability of bone formation and bone resorption as a function of the local mechanical stimulation (d) after implant insertion and (e) following 2 weeks of loading. * here denotes a significant difference (p < 0.001) between mean values of strains in formation and resorption surfaces. The full line corresponds to the mean and the shaded area to one standard deviation interval.