High dietary cholesterol and ovariectomy in rats repress gene expression of key markers of VLDL and bile acid metabolism in liver

Authors :: Zahra Farahnak
Emilienne T. Ngo Sock
Jean-Marc Lavoie
Isabelle M. Côté
Source :: Lipids in Health and Disease
Publication Year :: 2015
Publisher :: Springer Science and Business Media LLC, 2015.
Abstract: Background The purpose of the study was to evaluate the effects of high dietary cholesterol in ovariectomized (Ovx) rats on several key markers of hepatic cholesterol and bile acid metabolism. Method Ovx and sham operated (Sham) rats were given either a standard diet (SD), a SD diet supplemented with 0.25 % cholesterol (SD + Chol), or a high fat diet supplemented with 0.25 % cholesterol (HF + Chol) for 5 weeks. Results Ovx was associated with higher (P

Subjects :: medicine.medical_specialty
Very low-density lipoprotein
Clinical chemistry
Ovariectomy
Endocrinology, Diabetes and Metabolism
Cholesterol, VLDL
Clinical Biochemistry
Gene Expression
VLDL synthesis
Biology
Diet, High-Fat
digestive system
Bile Acids and Salts
Rats, Sprague-Dawley
chemistry.chemical_compound
Liver cholesterol
Endocrinology
Internal medicine
polycyclic compounds
medicine
Animals
Gene Silencing
Dyslipidemias
Biochemistry, medical
2. Zero hunger
Cholesterol
Research
Biochemistry (medical)
Reverse cholesterol transport
Cholesterol diet
Lipid metabolism
Lipid Metabolism
Liver
Receptors, LDL
chemistry
LDL receptor
Ovariectomized rat
LDL receptors
Female
lipids (amino acids, peptides, and proteins)
Biomarkers
Low Density Lipoprotein Receptor-Related Protein-1
Sterol Regulatory Element Binding Protein 2
Lipidology

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