Chemical Composition, Leishmanicidal and Cytotoxic Activities of the Essential Oils from Mangifera indica L. var. Rosa and Espada

The essential oils fromMangifera indicavar. Rosa and Espada latex were obtained by hydrodistillation and analyzed using GC-FID and GC-MS. Twenty-seven components were identified. The main compound in the essential oil fromM. indicavar. Espada (EOMiE) was terpinolene (73.6%). The essential oil ofM. indicavar. Rosa (EOMiR) was characterized by high amounts ofβ-pinene (40.7%) and terpinolene (28.3%). In the test for leishmanicidal activity against promastigotes forms ofL. amazonensis, EOMiR and EOMiE showed IC50(72 h) of 39.1 and 23.0 μg/mL, respectively. In macrophages, EOMiR and EOMiE showed CC50of 142.84 and 158.65 μg/mL, respectively. However, both were more specific to the parasite than macrophages, with values of selectivity index of 6.91 for EOMiE and 3.66 for EOMiR. The essential oils were evaluated for their cytotoxicity against the human tumor cells HEp-2, HT-29, NCI-H292, and HL-60. The EOMiR and EOMiE were most effective against the HL-60, with IC50values of 12.3 and 3.6 μg/mL, respectively. The results demonstrated that the essential oils ofM. indicacan destroyL. amazonensisand inhibit tumor cell growth. These findings contribute to the knowledge of the Brazilian biodiversity as a source of potential therapeutic agents.