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Emerging roles of Hippo signaling in inflammation and YAP-driven tumor immunity
- Source :
- Cancer letters. 426
- Publication Year :
- 2018
-
Abstract
- Initially identified as a cell and organ size controller, Hippo pathway turns into a hotspot for researchers. Within recent years, more and more mechanisms about Hippo pathway were uncovered. Even though Hippo signaling has been revealed to exert controversial roles according to different cell context and microenvironment, which is because of its diversified interplays with a great variety of signaling transduction cascades; mechanisms other than size-limitation, however, remain to be elucidated. Recently, a growing number of studies tend to put Hippo on inflammatory and immunological focus: its antimicrobial role in flies, its pro- or anti-inflammation in mammals, as well as its relevance to cancerous immunity. From inflammation to tumor immunogenicity, Hippo has been gradually justified to play a crucial role. This review summarized the latest findings regarding the involvement of Hippo pathway in immunity, and a more comprehensive understanding of Hippo pathway will shed light on clinical translational potential even precision medicine.
- Subjects :
- 0301 basic medicine
endocrine system
Cancer Research
animal structures
Immune microenvironment
Inflammation
Tumor immunity
Biology
Protein Serine-Threonine Kinases
03 medical and health sciences
Immunity
Neoplasms
medicine
Tumor Microenvironment
Animals
Humans
Hippo Signaling Pathway
Precision Medicine
Adaptor Proteins, Signal Transducing
Hippo signaling pathway
fungi
Signaling transduction
body regions
030104 developmental biology
Oncology
Hippo signaling
sense organs
medicine.symptom
Neuroscience
Signal Transduction
Subjects
Details
- ISSN :
- 18727980
- Volume :
- 426
- Database :
- OpenAIRE
- Journal :
- Cancer letters
- Accession number :
- edsair.doi.dedup.....18c5cbe0d7e7b99e1a02a20693640e2e