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Molecular characterization of the immune system: emergence of proteins, processes, and domains
- Source :
- Immunogenetics. 59:333-348
- Publication Year :
- 2007
- Publisher :
- Springer Science and Business Media LLC, 2007.
-
Abstract
- Many genes and proteins are required to carry out the processes of innate and adaptive immunity. For many studies, including systems biology, it is necessary to have a clear and comprehensive definition of the immune system, including the genes and proteins that take part in immunological processes. We have identified and cataloged a large portion of the human immunology-related genes, which we call the essential immunome. The 847 identified genes and proteins were annotated, and their chromosomal localizations were compared to the mouse genome. Relation to disease was also taken into account. We identified numerous pseudogenes, many of which are expressed, and found two putative new genes. We also carried out an evolutionary analysis of immune processes based on gene orthologs to gain an overview of the evolutionary past and molecular present of the human immune system. A list of genes and proteins were compiled. A comprehensive characterization of the member genes and proteins, including the corresponding pseudogenes is presented. Immunome genes were found to have three types of emergence in independent studies of their ontologies, domains, and functions.
- Subjects :
- medicine.medical_specialty
Pseudogene
Systems biology
Immunology
Biology
Genome
Evolution, Molecular
Mice
Immune system
Genetics
medicine
Animals
Chromosomes, Human
Humans
Gene
Genome, Human
Immunity
Chromosome Mapping
Computational Biology
Proteins
Acquired immune system
Human genetics
Protein Structure, Tertiary
Immune System
Medical genetics
Pseudogenes
Subjects
Details
- ISSN :
- 14321211 and 00937711
- Volume :
- 59
- Database :
- OpenAIRE
- Journal :
- Immunogenetics
- Accession number :
- edsair.doi.dedup.....18b069c4987f9f09b83be451bada5fae