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Overexpression of the peroxisome proliferator activated receptor α or the human c-Ha-ras transgene is not involved in tumorigenesis induced by di(2-ethylhexyl)phthalate in rasH2 mice
- Source :
- Cancer Letters. 192:199-203
- Publication Year :
- 2003
- Publisher :
- Elsevier BV, 2003.
-
Abstract
- The mRNA profiles for peroxisome proliferator activated receptor (PPAR) alpha and human c-Ha-ras genes were determined by real-time semi-quantitative polymerase chain reaction analysis of hepatocellular adenomas induced by di(2-ethylhexyl)phthalate (DEHP) in transgenic mice carrying a human prototype c-Ha-ras gene (rasH2 mice). The mRNA levels were essentially equal in hepatocellular adenomas and adjacent non-neoplastic hepatocytes, in spite of a remarkable elevation in the cell proliferation index in tumors determined by anti-Ki-67 immunohistochemistry. From the results, it is concluded that overexpression of PPARalpha or the transgene is not associated with the liver tumorigenesis induced by DEHP in rasH2 mice.
- Subjects :
- Male
Genetically modified mouse
endocrine system
Cancer Research
Transgene
Receptors, Cytoplasmic and Nuclear
Peroxisome proliferator-activated receptor
Mice, Transgenic
Biology
medicine.disease_cause
Adenoma, Liver Cell
Mice
chemistry.chemical_compound
Diethylhexyl Phthalate
medicine
Animals
Humans
RNA, Messenger
Transcription factor
chemistry.chemical_classification
Cell growth
Phthalate
Molecular biology
Gene Expression Regulation, Neoplastic
Genes, ras
Oncology
chemistry
Peroxisome proliferator-activated receptor alpha
Carcinogenesis
Cell Division
Transcription Factors
Subjects
Details
- ISSN :
- 03043835
- Volume :
- 192
- Database :
- OpenAIRE
- Journal :
- Cancer Letters
- Accession number :
- edsair.doi.dedup.....18a96e400aea101a187a5830b2ff16b6