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Processing and Physicochemical Properties of Magnetite Nanoparticles Coated with Curcuma longa L. Extract

Authors :
Margarita L. Alvarado-Noguez
Ana E. Matías-Reyes
Mario Pérez-González
Sergio A. Tomás
Claudia Hernández-Aguilar
Flavio A. Domínguez-Pacheco
Jesús A. Arenas-Alatorre
Alfredo Cruz-Orea
Mauricio D. Carbajal-Tinoco
Jairo Galot-Linaldi
Elizabet Estrada-Muñiz
Libia Vega-Loyo
Jaime Santoyo-Salazar
Source :
Materials; Volume 16; Issue 8; Pages: 3020
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

In this work, Curcuma longa L. extract has been used in the synthesis and direct coating of magnetite (Fe3O4) nanoparticles ~12 nm, providing a surface layer of polyphenol groups (–OH and –COOH). This contributes to the development of nanocarriers and triggers different bio-applications. Curcuma longa L. is part of the ginger family (Zingiberaceae); the extracts of this plant contain a polyphenol structure compound, and it has an affinity to be linked to Fe ions. The nanoparticles’ magnetization obtained corresponded to close hysteresis loop Ms = 8.81 emu/g, coercive field Hc = 26.67 Oe, and low remanence energy as iron oxide superparamagnetic nanoparticles (SPIONs). Furthermore, the synthesized nanoparticles (G-M@T) showed tunable single magnetic domain interactions with uniaxial anisotropy as addressable cores at 90–180°. Surface analysis revealed characteristic peaks of Fe 2p, O 1s, and C 1s. From the last one, it was possible to obtain the C–O, C=O, –OH bonds, achieving an acceptable connection with the HepG2 cell line. The G-M@T nanoparticles do not induce cell toxicity in human peripheral blood mononuclear cells or HepG2 cells in vitro, but they can increase the mitochondrial and lysosomal activity in HepG2 cells, probably related to an apoptotic cell death induction or to a stress response due to the high concentration of iron within the cell.

Details

ISSN :
19961944
Volume :
16
Database :
OpenAIRE
Journal :
Materials
Accession number :
edsair.doi.dedup.....18a52ebb31b3b62ef3bcf8cb08dbf6df
Full Text :
https://doi.org/10.3390/ma16083020