Back to Search
Start Over
Functional MRI connectivity of the primary motor cortex in functional dystonia patients
- Source :
- Journal of Neurology. 269:2961-2971
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Background: Functional movement disorders include a wide spectrum of clinically documented movement disorders without an apparent organic substrate. Objective: To explore the functional connectivity (FC) of the primary motor (M1) cortex in functional dystonia (FD) patients relative to healthy controls, with a focus on different clinical phenotypes. Methods: Forty FD patients (12 fixed [FixFD]; 28 mobile [MobFD]) and 43 healthy controls (14 young FixFD-age-matched [yHC]; 29 old MobFD-age-matched [oHC]) underwent resting state fMRI. A seed-based FC analysis was performed using bilateral M1 as regions of interest. Results: Compared to controls, FD patients showed reduced FC between left M1 and left dorsal anterior cingulate cortex, and between right M1 and left M1, premotor/supplementary motor area (SMA), dorsal posterior cingulate cortex (PCC), and bilateral precuneus. Relative to yHC, FixFD patients showed reduced FC between M1 and precuneus bilaterally. Compared to oHC, MobFD patients revealed reduced FC between right M1 and left M1, premotor/SMA, dorsal-PCC, bilateral primary sensory cortices and parieto-occipital areas, and increased FC of right M1 with right associative visual cortex and bilateral ventral-PCC. FixFD patients, relative to MobFD, showed lower FC between the right M1 and right associative visual area, and bilateral precuneus and ventral-PCC. Conclusions: This study suggests an altered brain FC of the motor circuit with areas involved in emotional processes and sense of agency in FD. FixFD patients showed FC abnormalities mainly in areas related to sense of agency, while MobFD in regions involved in sensorimotor functions (reduced FC) and emotional processing (increased FC).
- Subjects :
- Precuneus
Pathophysiology
03 medical and health sciences
0302 clinical medicine
Cortex (anatomy)
medicine
Humans
Anterior cingulate cortex
030304 developmental biology
Brain Mapping
0303 health sciences
Resting state fMRI
Supplementary motor area
business.industry
Motor Cortex
Brain
Magnetic Resonance Imaging
Psychogenic movement disorders (PMD)
Functional magnetic resonance imaging (fMRI)
Dystonia
medicine.anatomical_structure
Visual cortex
Neurology
Dystonic Disorders
Posterior cingulate
Neurology (clinical)
Primary motor cortex
business
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 14321459 and 03405354
- Volume :
- 269
- Database :
- OpenAIRE
- Journal :
- Journal of Neurology
- Accession number :
- edsair.doi.dedup.....18994b87ec2bc0e8fc65056afb695e20