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Status of internal quality control for thyroid hormones immunoassays from 2011 to 2016 in China
- Source :
- Journal of Clinical Laboratory Analysis. 32:e22154
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- Background Internal quality control (IQC) plays a key role in the evaluation of precision performance in clinical laboratories. This report aims to present precision status of thyroid hormones immunoassays from 2011 to 2016 in China. Methods Through Clinet-EQA reporting system, IQC information of Triiodothyronine and Thyroxine in the form of free and total (FT3, TT3, FT4, TT4), as well as Thyroid Stimulating Hormone (TSH) were collected from participant laboratories submitting IQC data in February, 2011-2016. For each analyte, current CVs were compared among different years and measurement systems. Percentages of laboratories meeting five allowable imprecision specifications (pass rates) were also calculated. Analysis of IQC practice was conducted to constitute a complete report. Results Current CVs were decreasing significantly but pass rates increasing only for FT3 during 6 years. FT3, TT3, FT4, and TT4 had the highest pass rates comparing with 1/3TEa imprecision specification but TSH had this comparing with minimum imprecision specification derived from biological variation. Constituent ratios of four mainstream measurement systems changed insignificantly. In 2016, precision performance of Abbott and Roche systems were better than Beckman and Siemens systems for all analytes except FT3 had Siemens also better than Beckman. Analysis of IQC practice demonstrated wide variation and great progress in aspects of IQC rules and control frequency. Conclusion With change of IQC practice, only FT3 had precision performance improved in 6 years. However, precision status of five analytes in China was still unsatisfying. Ongoing investigation and improvement of IQC have yet to be achieved.
- Subjects :
- Quality Control
Microbiology (medical)
China
Thyroid Hormones
030213 general clinical medicine
medicine.medical_specialty
Clinical Biochemistry
Siemens
Control (management)
03 medical and health sciences
0302 clinical medicine
Biological variation
Internal medicine
Statistics
medicine
Humans
Immunology and Allergy
Research Articles
Mathematics
Immunoassay
Biochemistry (medical)
Public Health, Environmental and Occupational Health
Reproducibility of Results
Hematology
Internal quality
Medical Laboratory Technology
Endocrinology
030220 oncology & carcinogenesis
Thyroid hormones
Reporting system
Performance specification
Subjects
Details
- ISSN :
- 08878013
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Laboratory Analysis
- Accession number :
- edsair.doi.dedup.....188fc90141cd7dbd1d315648fa0e888e