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Presence of pyrophosphate in bone from an atypical femoral fracture site: A case report
- Source :
- Bone Reports, Vol 6, Iss C, Pp 81-86 (2017), Bone Reports, Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Altres ajuts: The present study was supported by the Allgemeine Unfallversicherungsanstalt (AUVA), research funds of the Austrian workers compensation board, and the Wiener Gebietskrankenkasse (WGKK), Viennese sickness insurance funds. Long-term antiresorptives use has been linked to atypical subtrochanteric and diaphyseal femoral fractures (AFF), the pathogenesis of which is still unknown. In the present case report we present the results of analysis of bone chips from a 74-year old female patient that had been on alendronate, ibandronate and denosumab treatment, and who sustained an atypical femoral fracture, by histology, quantitative backscattered electron imaging, and Raman spectroscopic analysis. The results indicate ongoing osteoclastic resorption, but also several abnormalities: 1) an altered arrangement of osteons; 2) impaired mineralization; 3) the presence of pyrophosphate, which might contribute to the impaired mineralization evident in the present case. Taken together, these changes may contribute to the focally reduced bone strength of this patient.
- Subjects :
- 0301 basic medicine
Pathology
medicine.medical_specialty
Pyrophosphate
lcsh:Diseases of the musculoskeletal system
Endocrinology, Diabetes and Metabolism
030209 endocrinology & metabolism
Case Report
Pathogenesis
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Atypical femoral fracture
Osteoclastic resorption
Medicine
Orthopedics and Sports Medicine
Impaired mineralization
business.industry
Histology
Backscattered electron
Surgery
030104 developmental biology
Denosumab
chemistry
lcsh:RC925-935
business
Fractures
medicine.drug
Subjects
Details
- ISSN :
- 23521872
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Bone Reports
- Accession number :
- edsair.doi.dedup.....188dc32daa7c4959bf7c6121f8028e7a
- Full Text :
- https://doi.org/10.1016/j.bonr.2017.02.006