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Amino Acid Composition in Various Types of Nucleic Acid-Binding Proteins
- Source :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, Vol 22, Iss 922, p 922 (2021)
- Publication Year :
- 2020
-
Abstract
- Nucleic acid-binding proteins are traditionally divided into two categories: With the ability to bind DNA or RNA. In the light of new knowledge, such categorizing should be overcome because a large proportion of proteins can bind both DNA and RNA. Another even more important features of nucleic acid-binding proteins are so-called sequence or structure specificities. Proteins able to bind nucleic acids in a sequence-specific manner usually contain one or more of the well-defined structural motifs (zinc-fingers, leucine zipper, helix-turn-helix, or helix-loop-helix). In contrast, many proteins do not recognize nucleic acid sequence but rather local DNA or RNA structures (G-quadruplexes, i-motifs, triplexes, cruciforms, left-handed DNA/RNA form, and others). Finally, there are also proteins recognizing both sequence and local structural properties of nucleic acids (e.g., famous tumor suppressor p53). In this mini-review, we aim to summarize current knowledge about the amino acid composition of various types of nucleic acid-binding proteins with a special focus on significant enrichment and/or depletion in each category.
- Subjects :
- 0301 basic medicine
Leucine zipper
Plasma protein binding
Review
protein binding
DNA-binding protein
Catalysis
lcsh:Chemistry
Inorganic Chemistry
03 medical and health sciences
chemistry.chemical_compound
Z-RNA
DNA, Z-Form
Humans
triplex
Amino Acid Sequence
Physical and Theoretical Chemistry
Structural motif
i-motif
amino acid composition
lcsh:QH301-705.5
Molecular Biology
Spectroscopy
Leucine Zippers
030102 biochemistry & molecular biology
G-quadruplex
Chemistry
Organic Chemistry
Nucleic acid sequence
RNA
Zinc Fingers
General Medicine
DNA
Z-DNA
Computer Science Applications
DNA-Binding Proteins
G-Quadruplexes
030104 developmental biology
Nucleoproteins
lcsh:Biology (General)
lcsh:QD1-999
Biochemistry
Nucleic acid
cruciform
Nucleic Acid Conformation
Carrier Proteins
Subjects
Details
- ISSN :
- 14220067
- Volume :
- 22
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- International journal of molecular sciences
- Accession number :
- edsair.doi.dedup.....188dbc1eb272a15972e9d9e20d51e97c