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Amino Acid Composition in Various Types of Nucleic Acid-Binding Proteins

Authors :
Simona Guziurová
Kristyna Slychko
Jiří Červeň
Martin Bartas
Petr Pečinka
Source :
International Journal of Molecular Sciences, International Journal of Molecular Sciences, Vol 22, Iss 922, p 922 (2021)
Publication Year :
2020

Abstract

Nucleic acid-binding proteins are traditionally divided into two categories: With the ability to bind DNA or RNA. In the light of new knowledge, such categorizing should be overcome because a large proportion of proteins can bind both DNA and RNA. Another even more important features of nucleic acid-binding proteins are so-called sequence or structure specificities. Proteins able to bind nucleic acids in a sequence-specific manner usually contain one or more of the well-defined structural motifs (zinc-fingers, leucine zipper, helix-turn-helix, or helix-loop-helix). In contrast, many proteins do not recognize nucleic acid sequence but rather local DNA or RNA structures (G-quadruplexes, i-motifs, triplexes, cruciforms, left-handed DNA/RNA form, and others). Finally, there are also proteins recognizing both sequence and local structural properties of nucleic acids (e.g., famous tumor suppressor p53). In this mini-review, we aim to summarize current knowledge about the amino acid composition of various types of nucleic acid-binding proteins with a special focus on significant enrichment and/or depletion in each category.

Details

ISSN :
14220067
Volume :
22
Issue :
2
Database :
OpenAIRE
Journal :
International journal of molecular sciences
Accession number :
edsair.doi.dedup.....188dbc1eb272a15972e9d9e20d51e97c