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Some Mechanistic Insights into the Gelation of Regenerated Silk Fibroin Sol
- Source :
- Industrial & Engineering Chemistry Research. 48:8014-8023
- Publication Year :
- 2009
- Publisher :
- American Chemical Society (ACS), 2009.
-
Abstract
- We provide some new insights into the kinetics and mechanism of sol-gel transition as it pertains to regenerated silk fibroin, which is the principle structural protein of silkworm silk fiber. Silk fibroin was dissolved in lithium bromide and dialyzed against deionized water to prepare a regenerated fibroin solution. This solution was found to be unstable at lower pH and transformed into a colloidal gel. The kinetics and mechanism of the sol-gel transition were investigated using rheology and light scattering. We show that gelation proceeds in two steps. In the first step, a weak gel is formed almost immediately upon lowering the pH, while in the second step further gelation proceeds rapidly after a long induction time to form a self-similar structure.
- Subjects :
- Scaffolds
Gland
Rheological Behavior
Silk fiber
Lithium bromide
General Chemical Engineering
fungi
Kinetics
Structural protein
Proteins
Induction time
Fibroin
Hydrogels
General Chemistry
Bombyx-Mori
Gene
Industrial and Manufacturing Engineering
Biomaterials
chemistry.chemical_compound
Colloid
Rheometry
chemistry
Rheology
In-Vitro
Polymer chemistry
Subjects
Details
- ISSN :
- 15205045 and 08885885
- Volume :
- 48
- Database :
- OpenAIRE
- Journal :
- Industrial & Engineering Chemistry Research
- Accession number :
- edsair.doi.dedup.....187ecac18a02ed9852710a74104253ac