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Plasma Renin Activity Is an Independent Prognosticator in Patients With Myocardial Infarction
- Source :
- Circulation Journal. 83:1324-1329
- Publication Year :
- 2019
- Publisher :
- Japanese Circulation Society, 2019.
-
Abstract
- Background Plasma renin activity (PRA) is associated with cardiovascular events in patients with heart failure (HF), but its prognostic role in acute myocardial infarction (AMI) is unclear.Methods and Results:A total of 878 patients with information on baseline PRA on admission were selected from 1,055 AMI patients who underwent emergency coronary angiography between 2007 and 2016. The patients were divided into 2 groups according to their median PRA (2.0 ng/mL/h). The primary endpoint was major adverse cardiac events (MACE), defined as a composite of cardiovascular death and hospitalization because of HF. During follow-up (median 4.5±3.1 years), MACE occurred in 108 patients. Kaplan-Meier analysis showed that the high PRA group had significantly lower MACE-free survival than the low PRA group (log-rank P=0.0009). By multivariate analysis, high PRA was an independent predictor of MACE (hazard ratio (HR) 1.573; 95% confidence interval (CI) 1.049-2.396, P=0.0282). Similarly, among 580 patients who had not been previously treated with renin-angiotensin system inhibitors or β-blockers on admission, high PRA was an independent predictor of MACE (HR 1.732; 95% CI 1.010-3.047, P=0.0460). Conclusions In the studied AMI patients, elevated levels of PRA were independently associated with poor prognosis.
- Subjects :
- Male
medicine.medical_specialty
Multivariate analysis
Adrenergic beta-Antagonists
Myocardial Infarction
030204 cardiovascular system & hematology
Coronary Angiography
Plasma renin activity
Disease-Free Survival
Renin-Angiotensin System
03 medical and health sciences
0302 clinical medicine
Predictive Value of Tests
Internal medicine
Renin
Clinical endpoint
medicine
Humans
Registries
cardiovascular diseases
030212 general & internal medicine
Myocardial infarction
Aged
Aged, 80 and over
business.industry
Hazard ratio
General Medicine
Middle Aged
medicine.disease
Confidence interval
Survival Rate
Heart failure
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Mace
Subjects
Details
- ISSN :
- 13474820 and 13469843
- Volume :
- 83
- Database :
- OpenAIRE
- Journal :
- Circulation Journal
- Accession number :
- edsair.doi.dedup.....18798130256750b6686f3bf4be6d65ee