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Loss of the adhesion molecule CEACAM1 is associated with early biochemical recurrence inTMPRSS2:ERGfusion‐positive prostate cancers
- Source :
- International Journal of Cancer. 147:575-583
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Altered expression of the carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) has been linked to adverse tumor features in various cancer types. To better understand the role of CEACAM1 in prostate cancer, we analyzed a tissue microarray containing tumor spots from 17,747 prostate cancer patients by means of immunohistochemistry. Normal prostate glands showed intense membranous CEACAM1 positivity. Immunostaining was interpretable in 13,625 cancers and was considered high in 28%, low in 43% and absent in 29% of tumors. Low and lost CEACAM1 expression was strongly linked to adverse tumor features including high classical and quantitative Gleason grade, lymph node metastasis, advanced tumor stage, positive surgical margin, a high number of genomic deletions and early biochemical recurrence (p < 0.0001 each). Subset analysis of molecularly defined cancer subsets revealed that these associations were strongest in V-ets avian erythroblastosis virus E26 oncogene homolog (ERG) fusion-positive cancers and that CEACAM1 loss was prognostic even in tumors harboring genomic deletions of the phosphatase and tensin homolog tumor suppressor (p < 0.0001). Multivariate analysis suggested that CEACAM1 analysis can provide independent prognostic information beyond established prognosis parameters at the stage of the initial biopsy when therapy decisions must be taken. In conclusion, loss of CEACAM1 expression predicts poor prognosis in prostate cancer and might provide clinically useful prognostic information particularly in cancers harboring the TMPRSS2:ERG fusion.
- Subjects :
- Male
Biochemical recurrence
Cancer Research
Oncogene Proteins, Fusion
Down-Regulation
TMPRSS2
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Antigens, CD
Prostate
Biopsy
medicine
Humans
Sequence Deletion
Prostatectomy
Tissue microarray
Oncogene
medicine.diagnostic_test
business.industry
Prostatic Neoplasms
Cancer
Prostate-Specific Antigen
Prognosis
medicine.disease
Gene Expression Regulation, Neoplastic
Treatment Outcome
medicine.anatomical_structure
Oncology
Tissue Array Analysis
Lymphatic Metastasis
030220 oncology & carcinogenesis
Cancer research
Neoplasm Grading
business
Cell Adhesion Molecules
Subjects
Details
- ISSN :
- 10970215 and 00207136
- Volume :
- 147
- Database :
- OpenAIRE
- Journal :
- International Journal of Cancer
- Accession number :
- edsair.doi.dedup.....18616ecd89ba324a52cd62aecbf8587f