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Caspase-14—From Biomolecular Basics to Clinical Approach. A Review of Available Data
- Source :
- International Journal of Molecular Sciences, Vol 22, Iss 5575, p 5575 (2021), International Journal of Molecular Sciences
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Caspase-14 is a unique member of the caspase family—a family of molecules participating in apoptosis. However, it does not affect this process but regulates another form of programmed cell death—cornification, which is characteristic of the epidermis. Therefore, it plays a crucial role in the formation of the skin barrier. The cell death cycle has been a subject of interest for researchers for decades, so a lot of research has been done to expand the understanding of caspase-14, its role in cell homeostasis and processes affecting its expression and activation. Conversely, it is also an interesting target for clinical researchers searching for its role in the physiology of healthy individuals and its pathophysiology in particular diseases. A summary was done in 2008 by Denecker et al., concentrating mostly on the biotechnological aspects of the molecule and its physiological role. However, a lot of new data have been reported, and some more practical and clinical research has been conducted since then. The majority of studies tackled the issue of clinical data presenting the role of caspase in the etiopathology of many diseases such as retinal dysfunctions, multiple malignancies, and skin conditions. This review summarizes the available knowledge on the molecular and, more interestingly, the clinical aspects of caspase-14. It also presents how theoretical science may pave the way for medical research. Methods: The authors analyzed publications available on PubMed until 21 March 2021, using the search term “caspase 14”.
- Subjects :
- 0301 basic medicine
Skin barrier
QH301-705.5
cornification
Review
epidermis biology
Skin Diseases
caspase 14
Catalysis
Inorganic Chemistry
03 medical and health sciences
0302 clinical medicine
Retinal Diseases
Neoplasms
Animals
Homeostasis
Humans
Medicine
pathobiology
Biology (General)
Physical and Theoretical Chemistry
QD1-999
Molecular Biology
Spectroscopy
Caspase
biology
business.industry
Organic Chemistry
non-apoptotic caspase
Theoretical science
General Medicine
Medical research
Neoplasm Proteins
Computer Science Applications
Chemistry
030104 developmental biology
030220 oncology & carcinogenesis
Healthy individuals
biology.protein
business
Caspase 14
Neuroscience
Subjects
Details
- ISSN :
- 14220067
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....185196ff160e0f6b192366e13664447a
- Full Text :
- https://doi.org/10.3390/ijms22115575