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Double Trouble: A Case Series on Concomitant Genetic Aberrations in NSCLC
- Source :
- Van Der Steen, N, Mentens, Y, Ramael, M, Leon, L G, Germonpré, P, Ferri, J, Gandara, D R, Giovannetti, E, Peters, G J, Pauwels, P & Rolfo, C 2018, ' Double Trouble : A Case Series on Concomitant Genetic Aberrations in NSCLC ', Clinical Lung Cancer, vol. 19, no. 1, pp. 35-41 . https://doi.org/10.1016/j.cllc.2017.06.010, Clinical Lung Cancer, 19(1), 35-41. Elsevier, Clinical lung cancer
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Several oncogenic drivers have been identified in non-small cell lung cancer. Targeted therapies for these aberrations have already been successfully developed and implemented in clinical practice. Owing to improved sensitivity in genetic testing, more and more tumors with multiple driver mutations are identified, resulting in dilemmas for treating physicians whether and which targeted therapy to use. In this case series, we provide an overview of patients with intrinsic double mutations in oncogenic drivers and their reported response to targeted therapies, with a focus on epidermal growth factor receptor, anaplastic lymphoma kinase, cMET, and Kirsten rat sarcoma viral oncogene. We also include an unpublished case report on a patient with an epidermal growth factor receptor L858R and cMET exon 14 skipping.
- Subjects :
- 0301 basic medicine
Pulmonary and Respiratory Medicine
Cancer Research
Lung Neoplasms
medicine.medical_treatment
Viral Oncogene
medicine.disease_cause
Targeted therapy
Proto-Oncogene Proteins p21(ras)
03 medical and health sciences
Exon
0302 clinical medicine
Carcinoma, Non-Small-Cell Lung
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Anaplastic lymphoma kinase
Anaplastic Lymphoma Kinase
Genetic Testing
Molecular Targeted Therapy
Epidermal growth factor receptor
Neoplasm Metastasis
Lung cancer
Genetic testing
biology
medicine.diagnostic_test
business.industry
Middle Aged
Proto-Oncogene Proteins c-met
medicine.disease
ErbB Receptors
030104 developmental biology
Oncology
Drug Resistance, Neoplasm
030220 oncology & carcinogenesis
Mutation
Cancer research
biology.protein
Female
Human medicine
KRAS
business
Subjects
Details
- ISSN :
- 15257304
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Clinical Lung Cancer
- Accession number :
- edsair.doi.dedup.....184d2225d523195834ff5aba158882ed
- Full Text :
- https://doi.org/10.1016/j.cllc.2017.06.010