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Double Trouble: A Case Series on Concomitant Genetic Aberrations in NSCLC

Authors :
Yves Mentens
Jose Ferri
Godefridus J. Peters
Elisa Giovannetti
Nele Van Der Steen
Paul Germonpré
M. Ramael
Patrick Pauwels
Leticia G. Leon
David R. Gandara
Christian Rolfo
CCA - Cancer biology and immunology
Medical oncology laboratory
Medical oncology
CCA - Cancer Treatment and quality of life
Amsterdam Gastroenterology Endocrinology Metabolism
Source :
Van Der Steen, N, Mentens, Y, Ramael, M, Leon, L G, Germonpré, P, Ferri, J, Gandara, D R, Giovannetti, E, Peters, G J, Pauwels, P & Rolfo, C 2018, ' Double Trouble : A Case Series on Concomitant Genetic Aberrations in NSCLC ', Clinical Lung Cancer, vol. 19, no. 1, pp. 35-41 . https://doi.org/10.1016/j.cllc.2017.06.010, Clinical Lung Cancer, 19(1), 35-41. Elsevier, Clinical lung cancer
Publication Year :
2018
Publisher :
Elsevier BV, 2018.

Abstract

Several oncogenic drivers have been identified in non-small cell lung cancer. Targeted therapies for these aberrations have already been successfully developed and implemented in clinical practice. Owing to improved sensitivity in genetic testing, more and more tumors with multiple driver mutations are identified, resulting in dilemmas for treating physicians whether and which targeted therapy to use. In this case series, we provide an overview of patients with intrinsic double mutations in oncogenic drivers and their reported response to targeted therapies, with a focus on epidermal growth factor receptor, anaplastic lymphoma kinase, cMET, and Kirsten rat sarcoma viral oncogene. We also include an unpublished case report on a patient with an epidermal growth factor receptor L858R and cMET exon 14 skipping.

Details

ISSN :
15257304
Volume :
19
Database :
OpenAIRE
Journal :
Clinical Lung Cancer
Accession number :
edsair.doi.dedup.....184d2225d523195834ff5aba158882ed
Full Text :
https://doi.org/10.1016/j.cllc.2017.06.010