Apolipoprotein L1 Genotypes and the Association of Urinary Potassium Excretion with CKD Progression

Progressive CKD in Black individuals is strongly associated with polymorphisms in theWe analyzed 1399 self-identified Black participants enrolled in the Chronic Renal Insufficiency Cohort from April 2003 to September 2008. Exposures were calibrated 24-hour urine potassium and sodium excretion. The primary outcome was CKD progression defined as the time to 50% decline in eGFR or kidney failure. The secondary outcome was CKD progression or death. We tested for an interaction between urinary potassium and sodium excretion andMedian 24-hour urinary sodium and potassium excretions in Black participants were 150 mmol (interquartile range, 118-188) and 43 mmol (interquartile range, 35-54), respectively. Individuals with high- and low-riskHigher urinary potassium excretion was associated with lower versus higher risk of CKD progression in