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Oligometastatic recurrence as a prognostic factor after curative resection of esophageal squamous cell carcinoma
- Source :
- Surgery Today. 51:798-806
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- In recent years, the concept of oligometastasis, which represents limited metastatic disease, has gained much interest. This study focuses on the oligometastatic recurrence (OLR) of esophageal squamous cell carcinoma (ESCC) after esophagectomy. From among 514 patients who underwent curative resection for ESCC at our hospital between April 2005 and December 2019, 97 patients with recurrence were enrolled in this study. OLR was defined as fewer than five recurrences in a single organ. We analyzed the prognostic factors for patients with OLR after curative resection of ESCC, especially the relationship between the recurrence pattern and prognosis according to treatment, defined as metastasis-directed therapy (MDT) and chemotherapy with local therapy as combined local therapy (CLT). OLR was identified in 43 (44%) of the 97 patients with recurrence. The OLR group had a significantly better prognosis than the non-OLR group (P = 0.003). Multivariate analysis revealed that OLR was a prognostic factor after recurrence (P = 0.007) and that CLT after recurrence was the only prognostic factor in the OLR group (P = 0.024). The findings of this study suggest that OLR is a prognostic factor after resection of ESCC and that CLT is a promising treatment modality for patients with OLR after curative resection of ESCC.
- Subjects :
- Male
Curative resection
medicine.medical_specialty
Prognostic factor
Multivariate analysis
Esophageal Neoplasms
medicine.medical_treatment
Disease
Esophageal squamous cell carcinoma
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Surgical oncology
Internal medicine
Humans
Medicine
Neoplasm Metastasis
Chemotherapy
business.industry
General Medicine
Prognosis
Combined Modality Therapy
Esophagectomy
030220 oncology & carcinogenesis
Multivariate Analysis
Carcinoma, Squamous Cell
Female
030211 gastroenterology & hepatology
Surgery
Neoplasm Recurrence, Local
business
Subjects
Details
- ISSN :
- 14362813 and 09411291
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- Surgery Today
- Accession number :
- edsair.doi.dedup.....183a5eb004acb8e5cc06b34adb958006