Population of Monocyte-Derived Macrophages

Summary Dendritic cells (DCs), monocytes, and macrophages are leukocytes with critical roles in immunity and tolerance. The DC network is evolutionarily conserved; the homologs of human tissue CD141hiXCR1+CLEC9A+ DCs and CD1c+ DCs are murine CD103+ DCs and CD64−CD11b+ DCs. In addition, human tissues also contain CD14+ cells, currently designated as DCs, with an as-yet unknown murine counterpart. Here we have demonstrated that human dermal CD14+ cells are a tissue-resident population of monocyte-derived macrophages with a short half-life of
Graphical Abstract
Highlights • Human dermal CD14+ cells are a transient population of macrophages • Dermal CD14+ cells are derived from circulating blood monocytes • Human CD14+ cells are homologous to murine CD11b+CD64+ monocyte-derived macrophages • Human and mouse mononuclear phagocyte network organization is conserved
It is unclear whether human dermal CD14+ cells are bona fide dendritic cells. Haniffa and colleagues demonstrate that dermal CD14+ cells are monocyte-derived macrophages and complete the human and mouse tissue dendritic cell network alignment.